1: With acetic acid in 1,2-dichloro-ethane
T=20°C; 0.416667 h;
2: With sodium tris(acetoxy)borohydride in 1,2-dichloro-ethane
T=20°C;
3: With sodium hydroxide in water; 1,2-dichloro-ethane
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2006/100036 A1, 2006 ;
Location in patent: Page/Page column 206-207 ;
WO 2006/100036 A1
1: With borane-THF
Reflux;
2: With methanol
5 h; Reflux;
参考文献
Endeshaw, Molla M.; Li, Catherine; Leon, Jessica De; Yao, Ni; Latibeaudiere, Kirk; Premalatha, Kokku; Morrissette, Naomi; Werbovetz, Karl A.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 17 p. 5179 - 5183