[[2-(6-氨基-9H-嘌呤-9-基)乙氧基]甲基]膦酸二乙酯合成路线 （共 19 条）
反应条件
1: 9-(β-hydroxyethyl) adenine With Mg(O-t-Bu)2 in N,N-dimethyl-formamide T=20°C; 1 h; Inert atmosphere; 2: diethyl p-toluenesulfonyloxymethylphosphonate in N,N-dimethyl-formamide T=35°C; 20 h; Inert atmosphere;
参考文献
Roux, Loic; Priet, Stephane; Payrot, Nadine; Weck, Clement; Fournier, Maelenn; Zoulim, Fabien; Balzarini, Jan; Canard, Bruno; Alvarez, Karine
European Journal of Medicinal Chemistry, 2013 , vol. 63, p. 869 - 881
反应条件
sodium hydride in N,N-dimethyl-formamide T=80°C; 15 h;
参考文献
Holy, Antonin; Rosenberg, Ivan
Collection of Czechoslovak Chemical Communications, 1987 , vol. 52, # 11 p. 2801 - 2809
反应条件
ammonia in tetrahydrofuran; dimethyl sulfoxide T=25°C; 24 h;
参考文献
Dang, Qun; Liu, Yan; Erion, Mark D.
Nucleosides and Nucleotides, 1998 , vol. 17, # 8 p. 1445 - 1451
反应条件
sodium hydride in N,N-dimethyl-formamide T=80 - 90°C; 13 h;
参考文献
Holy, Antonin; Rosenberg, Ivan
Collection of Czechoslovak Chemical Communications, 1987 , vol. 52, # 11 p. 2801 - 2809
反应条件
sodium hydride in N,N-dimethyl-formamide T=100°C; 12 h;
参考文献
Holy, Antonin; Rosenberg, Ivan
Collection of Czechoslovak Chemical Communications, 1987 , vol. 52, # 11 p. 2801 - 2809
反应条件
1: 99 percent / Dowex 50X8 (H(+)-form) / ethanol / 30 h / Heating 2: 50 percent / CCl4, triphenylphosphine / 4 h / Heating 3: 46 percent / NaH / dimethylformamide / 15 h / 80 °C View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 52, # 11 p. 2801 - 2809
反应条件
1.1: 75 percent / triethylamine / diethyl ether / 0 - 20 °C 2.1: sodium tert-butoxide / dimethylformamide / 0.67 h / 20 °C 2.2: 27 percent / dimethylformamide / 72 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 26 p. 7799 - 7806
反应条件
1.1: NaH / dimethylformamide / 1 h / 60 °C 1.2: dimethylformamide / 16 h / 60 °C 2.1: 5.87 g / NH3 / methanol / 14 h / 20 °C 3.1: sodium tert-butoxide / dimethylformamide / 0.67 h / 20 °C 3.2: 27 percent / dimethylformamide / 72 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 26 p. 7799 - 7806
反应条件
1: 50 percent / CCl4, triphenylphosphine / 4 h / Heating 2: 46 percent / NaH / dimethylformamide / 15 h / 80 °C View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 52, # 11 p. 2801 - 2809
反应条件
1: 73 percent / dimethylformamide / 7 h / 120 °C 2: hydrazine / ethanol / 1 h / Heating 3: Et3N / ethanol / 20 h / Heating 4: 92 percent / 3 h / 120 °C 5: 87 percent / NH3 liquid / tetrahydrofuran; dimethylsulfoxide / 24 h / 25 °C View Scheme
参考文献
Nucleosides and Nucleotides, , vol. 17, # 8 p. 1445 - 1451
