[[2-(6-氨基-9H-嘌呤-9-基)乙氧基]甲基]膦酸二乙酯合成路线 （共 19 条）
反应条件
1: Et3N / ethanol / 20 h / Heating 2: 92 percent / 3 h / 120 °C 3: 87 percent / NH3 liquid / tetrahydrofuran; dimethylsulfoxide / 24 h / 25 °C View Scheme
参考文献
Nucleosides and Nucleotides, , vol. 17, # 8 p. 1445 - 1451
反应条件
1: hydrazine / ethanol / 1 h / Heating 2: Et3N / ethanol / 20 h / Heating 3: 92 percent / 3 h / 120 °C 4: 87 percent / NH3 liquid / tetrahydrofuran; dimethylsulfoxide / 24 h / 25 °C View Scheme
参考文献
Nucleosides and Nucleotides, , vol. 17, # 8 p. 1445 - 1451
反应条件
1: 92 percent / 3 h / 120 °C 2: 87 percent / NH3 liquid / tetrahydrofuran; dimethylsulfoxide / 24 h / 25 °C View Scheme
参考文献
Nucleosides and Nucleotides, , vol. 17, # 8 p. 1445 - 1451
反应条件
1: thionyl chloride / 1 h / Heating 2: 3 h / 60 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 12 p. 1857 - 1864
反应条件
T=60°C; 3 h; Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 12 p. 1857 - 1864
反应条件
trimethylsilyl bromide
参考文献
Nucleosides and Nucleotides, , vol. 17, # 8 p. 1445 - 1451
反应条件
1: diethyl-PMEA With 1-methyl-pyrrolidin-2-one; chloro-trimethyl-silane; sodium bromide T=60°C; 12 h; Inert atmosphere; 2: 2,2-Dimethyl-propionic acid chloromethyl ester With triethylamine T=60°C; 6 h;
参考文献
European Journal of Medicinal Chemistry, , vol. 63, p. 869 - 881
反应条件
1.1: water; hydrogen bromide / 4 h / 90 - 95 °C 1.2: 25 - 30 °C / pH 2.8 2.1: triethylamine; tetrabutylammomium bromide / ethyl acetate; N,N-dimethyl-formamide / 1 h / 25 - 35 °C 2.2: 25 - 35 °C View Scheme
反应条件
lithium aluminium tetrahydride; chloro-trimethyl-silane in tetrahydrofuran
T=-50 - 20°C;
参考文献
CENTRE NATIONAL DE RECHERCHE SCIENTIFIQUE (CNRS); UNIVERSITE DE LA MEDITERRANEE; K.U. LEUVEN RESEARCH and DEVELOPMENT
Patent: WO2008/56264 A2, 2008 ;
Location in patent: Page/Page column 69-70; 73-74; 81 ;
