(10,13-二甲基-3-氧代-1,2,4,5,6,7,8,9,11,12,14,15,16,17-十四氢环戊烯并[a]菲-17-基)乙酸酯合成路线 （共 3 条）
1164-91-6(10,13-二甲基-3-氧代-1,2,4,5,6,7,8,9,11,12,14,15,16,17-十四氢环戊烯并[a]菲-17-基)乙酸酯
→
反应条件
(diethylamido)sulfur trifluoride T=80°C; 3.5 h;
参考文献
Liu; Carlson; Katzenellenbogen
Journal of Medicinal Chemistry, 1992 , vol. 35, # 11 p. 2113 - 2129
1164-91-6(10,13-二甲基-3-氧代-1,2,4,5,6,7,8,9,11,12,14,15,16,17-十四氢环戊烯并[a]菲-17-基)乙酸酯
→
反应条件
1: 88 percent / hydrogen chloride; bromine / acetic acid / 1 h / 20 - 25 °C 2: 99.6 percent / lithium bromide; lithium carbonate / dimethylformamide / 0.5 h / Heating 3: 99.8 percent / sodium hydroxide / methanol / 2 h / 20 °C 4: 88.9 percent / chromium trioxide / acetic acid; H2O / 1 h / 25 - 30 °C View Scheme
参考文献
Zhang, Huyue; Qiu, Zhuibai
Steroids, 2006 , vol. 71, # 13-14 p. 1088 - 1090
1164-91-6(10,13-二甲基-3-氧代-1,2,4,5,6,7,8,9,11,12,14,15,16,17-十四氢环戊烯并[a]菲-17-基)乙酸酯
→
反应条件
1: 88 percent / hydrogen chloride; bromine / acetic acid / 1 h / 20 - 25 °C 2: 99.6 percent / lithium bromide; lithium carbonate / dimethylformamide / 0.5 h / Heating 3: 99.8 percent / sodium hydroxide / methanol / 2 h / 20 °C View Scheme
参考文献
Steroids, , vol. 71, # 13-14 p. 1088 - 1090
