5-氟-3,4-二氢-1H-喹啉-2-酮合成路线 （共 5 条）
反应条件
ammonium formate; palladium 10 on activated carbon in methanol 0.75 h; Reflux;
参考文献
WO2009/106534 A1, ;
Page/Page column 60-61 ;
WO 2009/106534 A1
反应条件
AlCl3, aluminium chloride T=120 - 125°C; 2 h;
参考文献
US2013/72679 A1, ;
Paragraph 0875; 0876 ;
反应条件
1: pyridine / dichloromethane / 3 h / 20 °C 2: AlCl3, aluminium chloride / 2 h / 120 - 125 °C View Scheme
参考文献
US2013/72679 A1, ;
WO2013/37779 A1, ;
US2013/79365 A1, ;
反应条件
1.1: dibenzoyl peroxide; N-bromosuccinmide / tetrachloromethane / 5 h / Reflux 2.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C 2.2: 0.75 h / 0 °C 3.1: ethanol; SnCl2·2H2O / 70 °C 4.1: hydrogenchloride; acetic acid / water / 1 h / 90 °C View Scheme
参考文献
WO2012/148808 A1, ;
WO 2012/148808 A1
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C 1.2: 0.75 h / 0 °C 2.1: ethanol; SnCl2·2H2O / 70 °C 3.1: hydrogenchloride; acetic acid / water / 1 h / 90 °C View Scheme
参考文献
WO2012/148808 A1, ;
WO 2012/148808 A1
