2,4-二氨基-6-乙氧基嘧啶合成路线 (共 7 条)
反应条件
sodium hydride 6 h; Reflux;
参考文献
Jang, Mi-Yeon; Jonghe, Steven De; Segers, Kenneth; Anne, Jozef; Herdewijn, Piet
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 1 p. 702 - 714
反应条件
1: 2,4-diamino-6-hydroxypyrimidine With sodium hydride in N,N-dimethyl-formamide; mineral oil 0.5 h; Inert atmosphere; 2: ethyl trifluoromethanesulphonate in N,N-dimethyl-formamide; mineral oil
参考文献
BAYER HEALTHCARE AG
Patent: US2010/35902 A1, 2010 ;
Location in patent: Page/Page column 20 ;
参考文献
Mueller, Hans-Georg; Hartke, Klaus
Archiv der Pharmazie (Weinheim, Germany), 1988 , vol. 321, p. 879 - 884
反应条件
1: 61 percent / H2S, pyridine / acetic acid / Ambient temperature 2: 93 percent / ethanol / Heating View Scheme
参考文献
Archiv der Pharmazie (Weinheim, Germany), , vol. 321, p. 879 - 884
反应条件
acetic acid; sodium nitrite in water
T=80°C;
参考文献
Marchetti, Francesco; Cano, Celine; Curtin, Nicola J.; Golding, Bernard T.; Griffin, Roger J.; Haggerty, Karen; Newell, David R.; Parsons, Rachel J.; Payne, Sara L.; Wang, Lan Z.; Hardcastle, Ian R.
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 10 p. 2397 - 2407
反应条件
1: HNO2
2: Na2S2O4; H2O
View Scheme
参考文献
Merck and Co. Inc.
Patent: US2584024 , 1948 ;