2,5-二氟-4-硝基苯甲酸合成路线 （共 6 条）
反应条件
sodium dichromate; sulfuric acid; acetic acid
参考文献
Thornton; Jackman; Marsham; O'Connor; Bishop; Calvert
Journal of Medicinal Chemistry, 1992 , vol. 35, # 12 p. 2321 - 2327
反应条件
1: 78 percent / fuming HNO3 / 0.5 h / 0 - 10 °C 2: 85 percent / Na2Cr2O7, AcOH, conc. H2SO4 View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 12 p. 2321 - 2327
反应条件
sulfuric acid Heating / reflux;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/84300 A1, 2008 ;
Location in patent: Page/Page column 68 ;
WO 2008/084300 A1
反应条件
hydrogen; palladium 10 on activated carbon in methanol P=3000.3 Torr;
参考文献
N.V. Organon and pharmacopeia, Inc.
Patent: US2009/264416 A1, 2009 ;
Location in patent: Page/Page column 23 ;
反应条件
1: oxalyl chloride, DMF / CH2Cl2 / 2.5 h
2: 100 percent / Et3N / CH2Cl2 / 1 h
View Scheme
参考文献
Thornton; Jackman; Marsham; O'Connor; Bishop; Calvert
Journal of Medicinal Chemistry, 1992 , vol. 35, # 12 p. 2321 - 2327
反应条件
1: With thionyl chloride; N,N-dimethyl-formamide in tetrahydrofuran
T=0°C; 1.5 h;
2: With ammonia; N-ethyl-N,N-diisopropylamine in tetrahydrofuran; 1,4-dioxane
T=0 - 50°C; 83 h;
参考文献
DEVELOGEN AKTIENGESELLSCHAFT
Patent: WO2006/136402 A1, 2006 ;
Location in patent: Page/Page column 95-96 ;
WO 2006/136402 A1
