N-叔丁氧羰基-赤式-鞘氨醇合成路线 （共 43 条）
反应条件
sodium bis(2-methoxyethoxy)aluminium dihydride in diethyl ether
T=20°C; 24 h;
参考文献
Suzuki, Hikokazu; Mori, Michiko; Shibakami, Motonari
Synlett, 2003 , # 14 p. 2163 - 2166
反应条件
1: 89 percent / HOBt; DCC / ethyl acetate / 16 h / 20 °C
2: 75 percent / Cu(I) thiophenecarboxylate; P(OEt)3 / Pd2(dba)3 / tetrahydrofuran; hexane / 10 h / 20 °C
3: Et2BOMe; NaBH4
View Scheme
参考文献
Yang, Hao; Liebeskind, Lanny S.
Organic Letters, 2007 , vol. 9, # 16 p. 2993 - 2995
反应条件
1: Et3N / dioxane; H2O / 3 h / 20 °C
2: N-methylmorpholine; EDCI*HCl / CH2Cl2 / 1 h / -15 °C
3: imidazole / dimethylformamide / 0.17 h / 0 °C
4: 92 percent / tetrahydrofuran / 0.17 h / 20 °C
5: 96 percent / LiAl(Ot-Bu)3H / ethanol / 0.25 h / -78 °C
6: 97 percent / aq. HCl / methanol / 0.25 h / 20 °C
7: 58 percent / (N,N'-Mes2-imidazolidin-2-yl)Ru=CHPh(PCy3)Cl2 / CH2Cl2 / 2 h / Heating
View Scheme
参考文献
Yamamoto, Tetsuya; Hasegawa, Hiroko; Hakogi, Toshikazu; Katsumura, Shigeo
Organic Letters, 2006 , vol. 8, # 24 p. 5569 - 5572
反应条件
1: 75 percent / Cu(I) thiophenecarboxylate; P(OEt)3 / Pd2(dba)3 / tetrahydrofuran; hexane / 10 h / 20 °C
2: Et2BOMe; NaBH4
View Scheme
参考文献
Yang, Hao; Liebeskind, Lanny S.
Organic Letters, 2007 , vol. 9, # 16 p. 2993 - 2995
反应条件
water; acetic acid; lithium chloride
T=20°C; 14 h; Inert atmosphere;
参考文献
Blot, Virginie; Jacquemard, Ulrich; Reissig, Hans-Ulrich; Kleuser, Burkhard
Synthesis, 2009 , # 5 p. 759 - 766
反应条件
2nd generation Grubbs catalyst in dichloromethane
2 h; Heating;
参考文献
Yamamoto, Tetsuya; Hasegawa, Hiroko; Hakogi, Toshikazu; Katsumura, Shigeo
Organic Letters, 2006 , vol. 8, # 24 p. 5569 - 5572
反应条件
1: 96 percent / LiAl(Ot-Bu)3H / ethanol / 0.25 h / -78 °C
2: 97 percent / aq. HCl / methanol / 0.25 h / 20 °C
3: 58 percent / (N,N'-Mes2-imidazolidin-2-yl)Ru=CHPh(PCy3)Cl2 / CH2Cl2 / 2 h / Heating
View Scheme
参考文献
Yamamoto, Tetsuya; Hasegawa, Hiroko; Hakogi, Toshikazu; Katsumura, Shigeo
Organic Letters, 2006 , vol. 8, # 24 p. 5569 - 5572
反应条件
1: imidazole / dimethylformamide / 0.17 h / 0 °C
2: 92 percent / tetrahydrofuran / 0.17 h / 20 °C
3: 96 percent / LiAl(Ot-Bu)3H / ethanol / 0.25 h / -78 °C
4: 97 percent / aq. HCl / methanol / 0.25 h / 20 °C
5: 58 percent / (N,N'-Mes2-imidazolidin-2-yl)Ru=CHPh(PCy3)Cl2 / CH2Cl2 / 2 h / Heating
View Scheme
参考文献
Yamamoto, Tetsuya; Hasegawa, Hiroko; Hakogi, Toshikazu; Katsumura, Shigeo
Organic Letters, 2006 , vol. 8, # 24 p. 5569 - 5572
反应条件
1: 97 percent / aq. HCl / methanol / 0.25 h / 20 °C
2: 58 percent / (N,N'-Mes2-imidazolidin-2-yl)Ru=CHPh(PCy3)Cl2 / CH2Cl2 / 2 h / Heating
View Scheme
参考文献
Yamamoto, Tetsuya; Hasegawa, Hiroko; Hakogi, Toshikazu; Katsumura, Shigeo
Organic Letters, 2006 , vol. 8, # 24 p. 5569 - 5572
反应条件
Grubb's 2nd generation catalyst in benzene
T=55°C;
参考文献
Hasegawa, Hiroko; Yamamoto, Tetsuya; Hatano, Sho; Hakogi, Toshikazu; Katsumura, Shigeo
Chemistry Letters, 2004 , vol. 33, # 12 p. 1592 - 1593
