5-氨基-3-(1-甲基-1,2,3,6-四氢吡啶-4-基)-1H-吲哚合成路线 (共 4 条)
反应条件
hydrazine in methanol T=20 - 65°C; 2 - 3 h; Product distribution / selectivity;
参考文献
Maddaford, Shawn; Ramnauth, Jailall; Rakhit, Suman; Patman, Joanne; Renton, Paul; Annedi, Subhash C.
Patent: US2006/258721 A1, 2006 ;
Location in patent: Page/Page column 49-51; 56 ;
US 20060258721 A1
反应条件
1: pyrrolidine / ethanol / Reflux 2: hydrazine hydrate / methanol View Scheme
参考文献
Annedi, Subhash C.; Maddaford, Shawn P.; Ramnauth, Jailall; Renton, Paul; Speed, Joanne; Rakhit, Suman; Andrews, John S.; Porreca, Frank
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 5 p. 1980 - 1984
反应条件
1: pyrrolidine / ethanol / Reflux 2: hydrazine hydrate / methanol View Scheme
参考文献
Annedi, Subhash C.; Maddaford, Shawn P.; Ramnauth, Jailall; Renton, Paul; Speed, Joanne; Rakhit, Suman; Andrews, John S.; Porreca, Frank
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 5 p. 1980 - 1984
反应条件
potassium hydroxide in methanol
参考文献
ELI LILLY AND COMPANY
Patent: EP824917 A2, 1998 ;
EP 0824917 A2