1-苯基-2-(4-苯基苯基)苯合成路线 （共 28 条）
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in water; N,N-dimethyl-formamide
T=0°C; Suzuki-Miyaura Coupling; 5 h; Inert atmosphere;
参考文献
Lima, Carlos F. R. A. C.; Rodrigues, Ana S. M. C.; Silva, Vera L. M.; Silva, Artur M. S.; Santos, Luis M. N. B. F.
ChemCatChem, 2014 , vol. 6, # 5 p. 1291 - 1302
反应条件
(i) aq. HCO2H, (ii) 2,3,5,6-tetrachloro<1,4>benzoquinone; Multistep reaction;
参考文献
Hey,D.H. et al.
Journal of the Chemical Society, 1961 , p. 748 - 750
反应条件
1: 1.) butylbromide/lithium / diethyl ether / 1.) rt., 3 h; 2.) rt., 48 h , then reflux, 2 h
2: oxalic acid / dioxane / 6 h / Heating
View Scheme
参考文献
Mochiike; Sakamoto; Hoshita
Chemical and pharmaceutical bulletin, 1983 , vol. 31, # 11 p. 3994 - 4000
反应条件
copper
1.) 265-270 deg C, 2 h; 2.) 270-275 deg C, 0.5 h;
参考文献
Ozasa; Fujioka; Tsukada; Ibuki
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 2 p. 344 - 355
反应条件
copper
1.) 265-270 deg C, 2 h; 2.) 270-275 deg C, 0.5 h;
参考文献
Ozasa; Fujioka; Tsukada; Ibuki
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 2 p. 344 - 355
反应条件
bis(acetylacetonate)nickel(II) in diethyl ether; benzene
1.) 0 deg C, 1 h 2.) reflux, 3 h;
参考文献
Ibuki; Ozasa; Fujioka; et al.
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 7 p. 2369 - 2379
反应条件
1: 1.) butylbromide/lithium / diethyl ether / 1.) rt., 3 h; 2.) rt., 48 h , then reflux, 2 h
2: oxalic acid / dioxane / 6 h / Heating
View Scheme
参考文献
Mochiike; Sakamoto; Hoshita
Chemical and pharmaceutical bulletin, 1983 , vol. 31, # 11 p. 3994 - 4000
反应条件
1: (i) Mg, (ii) /BRN= 1368883/
2: Pd-C / 290 °C
View Scheme
参考文献
Woods,G.F.; Scotti,F.
Journal of Organic Chemistry, 1961 , vol. 26, p. 312 - 318
反应条件
1: 19 percent / copper powder / 235 - 240 °C
2: 95 percent / iron (activated) / benzene / Heating
3: 1.) NaNO2, conc. H2SO4; 2.) KI / 1.) water, 0-5 deg C, 2 h; 2.) water, 0-5 deg C
4: 154 mg / copper powder / 1.) 265-270 deg C, 2 h; 2.) 270-275 deg C, 0.5 h
View Scheme
参考文献
Ozasa; Fujioka; Tsukada; Ibuki
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 2 p. 344 - 355
反应条件
1: 93 percent / iron (activated) / benzene / Heating
2: 1.) NaNO2, conc. H2SO4; 2.) KI / 1.) water, 0-5 deg C; 2.) water, 0-5 deg C
3: 206 mg / copper powder / 1.) 265-270 deg C, 2 h; 2.) 270-275 deg C, 0.5 h
View Scheme
参考文献
Ozasa; Fujioka; Tsukada; Ibuki
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 2 p. 344 - 355
