(S)-(-)-3-(N-甲氨基)-1-(2-噻吩基)-1-丙醇合成路线 （共 57 条）
反应条件
hydrogen; potassium carbonate; RuCl2 in isopropyl alcohol T=30°C; P=18751.9 Torr; 18 h;
参考文献
EP1411045 A1, ;
Page 19 ;
反应条件
potassium tert-butylate; hydrogen; [(R)-Binap RuCl2 (R)-DAIPEN] in isopropyl alcohol T=80°C; P=7500.75 Torr; 16 h; Inert atmosphere;
参考文献
US2013/5992 A1, ;
Page/Page column 3 ;
反应条件
hydrogen; Raney-nickel in methanol T=50°C; 12 h; Autoclave;
参考文献
US2011/275835 A1, ;
Page/Page column 3 ;
反应条件
1: With sodium tetrahydroborate; iodine in tetrahydrofuran T=20°C; 4.33333 h; Heating / reflux; 2: With sodium hydroxide; water in tetrahydrofuran; water; butanone T=64°C; 0.333333 h;
参考文献
EP1486493 A1, ;
Page 33 ;
反应条件
1: With acetic acid; zinc in water T=50°C; 1.5 h; 2: With sodium hydroxide in water
参考文献
US2008/171887 A1, ;
Page/Page column 7 ;
反应条件
water; sodium carbonate in methanol T=20°C; 4 h;
参考文献
WO2010/3942 A2, ;
Page/Page column 23 ;
反应条件
sodium hydroxide; (p-cymene)-ruthenium(II) chloride dimer in isopropyl alcohol T=20 - 85°C; 5 h;
参考文献
WO2004/31168 A2, ;
Page 15 ;
反应条件
1: With triethylamine in toluene T=20 - 30°C; 6 h; 2: With potassium hydroxide in methanol T=75°C; 3.5 h; Heating / reflux;
参考文献
EP1506965 A1, ;
Page/Page column 35 ;
反应条件
potassium hydroxide in methanol T=70°C; 2 h;
参考文献
EP1506965 A1, ;
Page/Page column 27 ;
反应条件
sodium iodide; tetrabutylammomium bromide in methanol; water T=60 - 65°C; 6 - 8 h;
参考文献
EP2060559 A1, ;
Page/Page column 8 ;
