(S)-(-)-3-(N-甲氨基)-1-(2-噻吩基)-1-丙醇合成路线 （共 57 条）
反应条件
1: With hydrogen; potassium carbonate; [Rh(NBD)(Rp,Rp,Sc,Sc-DuanPhos)]BF4 in methanol; water T=25 - 55°C; P=22502.3 Torr; 5 h; 2: With sodium hydroxide in tert-butyl methyl ether; water Product distribution / selectivity;
参考文献
WO2006/87166 A1, ;
Page/Page column 25-27 ;
反应条件
1: With hydrogen; potassium carbonate; [Rh(NBD)(Rp,Rp,Sc,Sc-DuanPhos)]BF4 in methanol; water T=25°C; P=7500.75 - 22502.3 Torr; 5 - 41 h; 2: With sodium hydroxide in tert-butyl methyl ether; water Product distribution / selectivity;
参考文献
WO2006/87166 A1, ;
Page/Page column 25-27 ;
反应条件
1: With hydrogen; potassium carbonate; [Rh(NBD)(Rp,Rp,Sc,Sc-DuanPhos)]BF4 in methanol; water T=25°C; P=22502.3 Torr; 5 h; 2: With sodium hydroxide in tert-butyl methyl ether; water Product distribution / selectivity;
参考文献
WO2006/87166 A1, ;
Page/Page column 25-27 ;
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran T=20°C; 3 h;
参考文献
Tetrahedron Asymmetry, , vol. 24, # 15-16 p. 913 - 918
反应条件
1: With triethylamine in tert-butyl methyl ether T=-5 - 20°C; 4 h; 2: With potassium hydroxide in methanol; tert-butyl methyl ether 2 h; Heating / reflux;
参考文献
EP1506965 A1, ;
Page/Page column 33 ;
反应条件
1: HCl / ethanol / 110 °C 2: 93 percent / hydrogen; K2CO3 / [Rh{(SC,RP)-duanphos}(norbornadiene)]SbF6 / methanol / 12 h / 20 °C / 7500.6 Torr View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 44, # 11 p. 1687 - 1689
反应条件
in tetrahydrofuran; water T=25°C; 12 h; Inert atmosphere;
参考文献
Organic and Biomolecular Chemistry, , vol. 12, # 6 p. 1009 - 1017
反应条件
in tetrahydrofuran; water T=65°C; 3 h;
参考文献
Advanced Synthesis and Catalysis, , vol. 345, # 1-2 p. 261 - 274
反应条件
hydrogen; nickel in methanol; water T=65°C; P=37503.8 Torr; 24 h; Product distribution / selectivity;
参考文献
WO2004/13123 A1, ;
Page/Page column 20 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 1.5 h; Heating;
参考文献
Tetrahedron Letters, , vol. 44, # 25 p. 4783 - 4787
