(S)-(-)-3-(N-甲氨基)-1-(2-噻吩基)-1-丙醇合成路线 （共 57 条）
反应条件
(S)-α-hydroxybenzeneacetic acid in water T=29 - 50°C;
参考文献
Tetrahedron Asymmetry, , vol. 14, # 12 p. 1631 - 1636
反应条件
1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 10 h / 20 °C 1.2: 90 percent / tetrahydrofuran / 18 h / 20 °C 2.1: H2 / RuBr2((R)-(6,6'-(MeO)2-biphenyl-2,2'-diyl)bis(Ph2-phosphane) / methanol / 72 h / 25 °C / 760.05 Torr 3.1: 82 percent / LiAlH4 / tetrahydrofuran; diethyl ether / 1.5 h / 0 - 20 °C 4.1: 78 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C 5.1: 94 percent / tetrahydrofuran; H2O / 3 h / 65 °C View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 345, # 1-2 p. 261 - 274
反应条件
1: H2 / RuBr2((R)-(6,6'-(MeO)2-biphenyl-2,2'-diyl)bis(Ph2-phosphane) / methanol / 72 h / 25 °C / 760.05 Torr 2: 82 percent / LiAlH4 / tetrahydrofuran; diethyl ether / 1.5 h / 0 - 20 °C 3: 78 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C 4: 94 percent / tetrahydrofuran; H2O / 3 h / 65 °C View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 345, # 1-2 p. 261 - 274
反应条件
water; lithium hydroxide hydrate in methanol 8 h; Reflux;
参考文献
Arkivoc, , vol. 2010, # 10 p. 55 - 61
反应条件
hydrogenchloride in tetrahydrofuran; water T=20°C; 4 h;
参考文献
Tetrahedron, , vol. 62, # 52 p. 12270 - 12280
反应条件
1: LiHMDS / tetrahydrofuran / 0 - 20 °C 2: Ph2SiH2 / RhH(CO)(PPh3)3 / tetrahydrofuran / 15 h / 20 °C 3: HCl / H2O; tetrahydrofuran / 4 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 62, # 52 p. 12270 - 12280
反应条件
1: Ph2SiH2 / RhH(CO)(PPh3)3 / tetrahydrofuran / 15 h / 20 °C 2: HCl / H2O; tetrahydrofuran / 4 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 62, # 52 p. 12270 - 12280
反应条件
1: 36 percent / BF3*Et2O / CH2Cl2 / -78 - 20 °C 2: aluminum amalgam / propan-2-ol 3: LiHMDS / tetrahydrofuran / 0 - 20 °C 4: Ph2SiH2 / RhH(CO)(PPh3)3 / tetrahydrofuran / 15 h / 20 °C 5: HCl / H2O; tetrahydrofuran / 4 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 62, # 52 p. 12270 - 12280
反应条件
1: aluminum amalgam / propan-2-ol 2: LiHMDS / tetrahydrofuran / 0 - 20 °C 3: Ph2SiH2 / RhH(CO)(PPh3)3 / tetrahydrofuran / 15 h / 20 °C 4: HCl / H2O; tetrahydrofuran / 4 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 62, # 52 p. 12270 - 12280
反应条件
1: (R)-1-Me-3,3-Ph2-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; BH3 / tetrahydrofuran 2: NaI / acetone 3: tetrahydrofuran View Scheme
参考文献
Bioorganic and medicinal chemistry letters, , vol. 13, # 24 p. 4477 - 4480
