(S)-(-)-3-(N-甲氨基)-1-(2-噻吩基)-1-丙醇合成路线 （共 57 条）
反应条件
1: NaI / acetone 2: tetrahydrofuran View Scheme
参考文献
Bioorganic and medicinal chemistry letters, , vol. 13, # 24 p. 4477 - 4480
反应条件
1: 82 percent / LiAlH4 / tetrahydrofuran; diethyl ether / 1.5 h / 0 - 20 °C 2: 78 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C 3: 94 percent / tetrahydrofuran; H2O / 3 h / 65 °C View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 345, # 1-2 p. 261 - 274
反应条件
1: 78 percent / Et3N / diethyl ether / 3 h / -10 - 0 °C 2: 94 percent / tetrahydrofuran; H2O / 3 h / 65 °C View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 345, # 1-2 p. 261 - 274
反应条件
1: hydrogen; potassium tert-butylate / RuCl2[(R)-(DM-BINAP)][(R)-DAIPEN] / methanol / 12 h / 20 °C / Autoclave 2: Raney-nickel / methanol / 12 h / 50 °C / Autoclave View Scheme
反应条件
1: hydrogenchloride / water / 2 h / 21 °C 2: toluene / 0.5 h / 80 °C 3: sodium hydroxide / water 4: sodium hydrogencarbonate / toluene / 90 °C 5: sodium hydrogencarbonate / toluene / 0.33 h / 120 °C / |Dean-Stark 6: sodium hydroxide / water; ethanol / 3 h / 82 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 10, # 5 p. 905 - 913
反应条件
1: K2CO3 / CH2Cl2; tetrahydrofuran / 0.5 h / 20 °C 2: 88 percent / LAH / tetrahydrofuran / 1.5 h / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 44, # 25 p. 4783 - 4787
反应条件
1: 3-chloro-1-(thiophen-2-yl)propan-1-one With sodium hydroxide; D-glucose; mannose in water T=30°C; pH=6.0; 2 - 8 h; 2: methylamine in water T=60°C; pH=6.0; 6 h;
参考文献
WO2005/33094 A2, ;
Page/Page column 43-44 ;
反应条件
1: sodium tetrahydroborate; sodium hydroxide / water / 7 h / 20 - 71 °C 2: toluene / 0.5 h / 80 °C 3: sodium hydroxide / water 4: sodium hydrogencarbonate / toluene / 90 °C 5: sodium hydrogencarbonate / toluene / 0.33 h / 120 °C / |Dean-Stark 6: sodium hydroxide / water; ethanol / 3 h / 82 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 10, # 5 p. 905 - 913
反应条件
1: toluene / 0.5 h / 80 °C 2: sodium hydroxide / water 3: sodium hydrogencarbonate / toluene / 90 °C 4: sodium hydrogencarbonate / toluene / 0.33 h / 120 °C / |Dean-Stark 5: sodium hydroxide / water; ethanol / 3 h / 82 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 10, # 5 p. 905 - 913
反应条件
1: 90 percent / NaBH4 / methanol / 0.5 h / 20 °C 2: 77 percent / methanol; H2O / 4 h / 20 °C 3: 42 percent / immobilised lipase from Pseudomonas cepacia; phosphate buffer / diisopropyl ether / 14 h / pH 7.2 4: BH3*Me2S / tetrahydrofuran / 2 h / Heating 5: K2CO3 / CH2Cl2; tetrahydrofuran / 0.5 h / 20 °C 6: 88 percent / LAH / tetrahydrofuran / 1.5 h / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 44, # 25 p. 4783 - 4787
