(S)-(-)-3-(N-甲氨基)-1-(2-噻吩基)-1-丙醇合成路线 （共 57 条）
反应条件
1: 77 percent / methanol; H2O / 4 h / 20 °C 2: 42 percent / immobilised lipase from Pseudomonas cepacia; phosphate buffer / diisopropyl ether / 14 h / pH 7.2 3: BH3*Me2S / tetrahydrofuran / 2 h / Heating 4: K2CO3 / CH2Cl2; tetrahydrofuran / 0.5 h / 20 °C 5: 88 percent / LAH / tetrahydrofuran / 1.5 h / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 44, # 25 p. 4783 - 4787
反应条件
1: 42 percent / immobilised lipase from Pseudomonas cepacia; phosphate buffer / diisopropyl ether / 14 h / pH 7.2 2: BH3*Me2S / tetrahydrofuran / 2 h / Heating 3: K2CO3 / CH2Cl2; tetrahydrofuran / 0.5 h / 20 °C 4: 88 percent / LAH / tetrahydrofuran / 1.5 h / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 44, # 25 p. 4783 - 4787
反应条件
1: BH3*Me2S / tetrahydrofuran / 2 h / Heating 2: K2CO3 / CH2Cl2; tetrahydrofuran / 0.5 h / 20 °C 3: 88 percent / LAH / tetrahydrofuran / 1.5 h / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 44, # 25 p. 4783 - 4787
反应条件
1: BH3*Me2S / tetrahydrofuran / 2 h / Heating 2: K2CO3 / CH2Cl2; tetrahydrofuran / 0.5 h / 20 °C 3: 88 percent / LAH / tetrahydrofuran / 1.5 h / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 44, # 25 p. 4783 - 4787
反应条件
1: sodium hydrogencarbonate / toluene / 90 °C 2: sodium hydrogencarbonate / toluene / 0.33 h / 120 °C / |Dean-Stark 3: sodium hydroxide / water; ethanol / 3 h / 82 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 10, # 5 p. 905 - 913
反应条件
1: sodium hydroxide / water 2: sodium hydrogencarbonate / toluene / 90 °C 3: sodium hydrogencarbonate / toluene / 0.33 h / 120 °C / |Dean-Stark 4: sodium hydroxide / water; ethanol / 3 h / 82 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 10, # 5 p. 905 - 913
反应条件
1: tetrakis(triphenylphosphine) palladium(0); N,N'-dimethyl-barbituric acid / dichloromethane / 6 h / 50 °C 2: potassium carbonate / dichloromethane; water / 2.5 h / 20 °C 3: lithium aluminium tetrahydride / tetrahydrofuran / 48 h / Reflux View Scheme
参考文献
Journal of Organic Chemistry, , vol. 77, # 9 p. 4496 - 4500
反应条件
1.1: 1H-imidazole; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 6 h / 0 - 20 °C 2.1: diisobutylaluminium hydride / dichloromethane / 1 h / -45 °C / |Inert atmosphere 3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / 0 °C 3.2: 1 h / 20 °C 4.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 0 °C 4.2: 3.5 h / 0 °C 5.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C 6.1: water; tetrahydrofuran / 3 h / 65 °C 7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 24, # 15-16 p. 913 - 918
反应条件
1.1: diisobutylaluminium hydride / dichloromethane / 1 h / -45 °C / |Inert atmosphere 2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / 0 °C 2.2: 1 h / 20 °C 3.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 0 °C 3.2: 3.5 h / 0 °C 4.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C 5.1: water; tetrahydrofuran / 3 h / 65 °C 6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 24, # 15-16 p. 913 - 918
反应条件
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / 0 °C 1.2: 1 h / 20 °C 2.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 0 °C 2.2: 3.5 h / 0 °C 3.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C 4.1: water; tetrahydrofuran / 3 h / 65 °C 5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 24, # 15-16 p. 913 - 918
