(S)-(-)-3-(N-甲氨基)-1-(2-噻吩基)-1-丙醇合成路线 （共 57 条）
反应条件
1.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 0 °C 1.2: 3.5 h / 0 °C 2.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C 3.1: water; tetrahydrofuran / 3 h / 65 °C 4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 24, # 15-16 p. 913 - 918
反应条件
1: triethylamine / dichloromethane / 2 h / 0 - 20 °C 2: water; tetrahydrofuran / 3 h / 65 °C 3: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 24, # 15-16 p. 913 - 918
反应条件
1: water; tetrahydrofuran / 3 h / 65 °C 2: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 24, # 15-16 p. 913 - 918
反应条件
in methanol; water T=75°C; 20 h;
参考文献
WO2005/73215 A1, ;
Page/Page column 4 ;
反应条件
potassium tert-butylate in dimethyl sulfoxide T=60°C; 8 h;
参考文献
SCI Pharmatech, Inc.
Patent: EP2386549 A1, 2011 ;
Location in patent: Page/Page column 6-7 ;
反应条件
potassium tert-butylate in dimethyl sulfoxide T=60°C; 8 h;
参考文献
SCI Pharmatech, Inc.
Patent: EP2386549 A1, 2011 ;
Location in patent: Page/Page column 6-7 ;
反应条件
1: With sodium hydride in paraffin oil (nujol); dimethyl sulfoxide T=20 - 50°C; 2: With hydrogenchloride; acetic acid in isopropanol acetate T=0 - 15°C; 5 h;
参考文献
KRKA, D.D., NOVO MESTO; BOMBEK, Sergeja; MERSLAVIC, Marjo; BENKIC, Primoz; ZAJC, Natalija; VRECER, Franc
Patent: WO2011/128370 A1, 2011 ;
Location in patent: Page/Page column 21 ;
