3-甲基氨基-1-(2-噻吩)-1-丙醇合成路线 （共 7 条）
反应条件
(S)-α-hydroxybenzeneacetic acid in water T=29 - 50°C;
参考文献
Tetrahedron Asymmetry, , vol. 14, # 12 p. 1631 - 1636
反应条件
hydrogen; nickel in methanol
T=50°C; 12 h;
参考文献
SCI Pharmtech, Inc.
Patent: US2009/112000 A1, 2009 ;
Location in patent: Page/Page column 3-4 ;
反应条件
1: With sodium tetrahydroborate; acetic acid in toluene
T=50 - 80°C; 2 h;
2: With sodium hydroxide in water; toluene
T=25°C;
参考文献
SUMITOMO SEIKA CHEMICALS CO., LTD.
Patent: EP1541569 A1, 2005 ;
Location in patent: Page/Page column 6; 7 ;
反应条件
1: HCl / ethanol / 110 °C
2: NaBH4 / methanol / 1 h / 20 °C
View Scheme
参考文献
Liu, Duan; Gao, Wenzhong; Wang, Chunjiang; Zhang, Xumu
Angewandte Chemie - International Edition, 2005 , vol. 44, # 11 p. 1687 - 1689
反应条件
1.1: 23 percent / BF3*Et2O / CH2Cl2 / -78 - 20 °C
2.1: aluminum amalgam / propan-2-ol
3.1: LiHMDS / tetrahydrofuran / 0 - 20 °C
4.1: Ph2SiH2 / RhH(CO)(PPh3)3 / tetrahydrofuran / 15 h / 20 °C
4.2: HCl / H2O; tetrahydrofuran / 4 h / 20 °C
View Scheme
参考文献
Panunzio, Mauro; Tamanini, Emiliano; Bandini, Elisa; Campana, Eileen; D'Aurizio, Antonio; Vicennati, Paola
Tetrahedron, 2006 , vol. 62, # 52 p. 12270 - 12280
反应条件
1: 3-chloro-1-(thiophen-2-yl)propan-1-one With sodium hydroxide; sodium tetrahydroborate in methanol; water; toluene
T=0°C; 3.16667 h;
2: methylamine in methanol; water; toluene
T=60°C; 6 h;
参考文献
BASF AKTIENGESELLSCHAFT
Patent: WO2005/33094 A2, 2005 ;
Location in patent: Page/Page column 33 ;
反应条件
(S)-α-hydroxybenzeneacetic acid in water
T=29 - 50°C;
参考文献
Sakai, Kenichi; Sakurai, Rumiko; Yuzawa, Atsushi; Kobayashi, Yuka; Saigo, Kazuhiko
Tetrahedron Asymmetry, 2003 , vol. 14, # 12 p. 1631 - 1636
