(R)-3-甲基氨基-1-(2-噻吩基)-1-丙醇合成路线 （共 22 条）
反应条件
1: 88 percent / triethyl amine / CH2Cl2 / 2 h / 20 °C 2: 51 percent / PPh3; DIAD / tetrahydrofuran / 24 h 3: 70 percent / TFA / CHCl3 View Scheme
参考文献
Kamal, Ahmed; Khanna, G. B. Ramesh; Ramu; Krishnaji
Tetrahedron Letters, 2003 , vol. 44, # 25 p. 4783 - 4787
反应条件
1: 88 percent / triethyl amine / CH2Cl2 / 2 h / 20 °C 2: 51 percent / PPh3; DIAD / tetrahydrofuran / 24 h 3: 70 percent / TFA / CHCl3 View Scheme
参考文献
Kamal, Ahmed; Khanna, G. B. Ramesh; Ramu; Krishnaji
Tetrahedron Letters, 2003 , vol. 44, # 25 p. 4783 - 4787
反应条件
sodium hydroxide; (p-cymene)-ruthenium(II) chloride dimer in isopropyl alcohol
T=20 - 85°C; 5 h;
参考文献
Lonza AG
Patent: WO2004/31168 A2, 2004 ;
Location in patent: Page 15 ;
反应条件
1: With acetic acid; zinc in water
T=50°C; 1.5 h;
2: With sodium hydroxide in water
参考文献
Pospisilik, Karel; Dymacek, Bohumil
Patent: US2008/171887 A1, 2008 ;
Location in patent: Page/Page column 7 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
1.5 h; Heating;
参考文献
Kamal, Ahmed; Khanna, G. B. Ramesh; Ramu; Krishnaji
Tetrahedron Letters, 2003 , vol. 44, # 25 p. 4783 - 4787
反应条件
1: HCl / ethanol / 110 °C
2: 93 percent / hydrogen; K2CO3 / [Rh{(RC,SP)-duanphos}(norbornadiene)]SbF6 / methanol / 12 h / 20 °C / 7500.6 Torr
View Scheme
参考文献
Liu, Duan; Gao, Wenzhong; Wang, Chunjiang; Zhang, Xumu
Angewandte Chemie - International Edition, 2005 , vol. 44, # 11 p. 1687 - 1689
反应条件
(S)-α-hydroxybenzeneacetic acid in water
T=29 - 50°C;
参考文献
Sakai, Kenichi; Sakurai, Rumiko; Yuzawa, Atsushi; Kobayashi, Yuka; Saigo, Kazuhiko
Tetrahedron Asymmetry, 2003 , vol. 14, # 12 p. 1631 - 1636
反应条件
trans-{Ru[(S)-xylbinap][(S)-daipen]Cl2}; potassium tert-butylate; hydrogen in isopropyl alcohol
T=20°C; P=750.075 Torr; 24 h; Autoclave; optical yield given as percent eeenantioselective reaction;
参考文献
Geng, Huiling; Zhang, Xiaowei; Chang, Mingxin; Zhou, Le; Wu, Wenjun; Zhang, Xumu
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 16 p. 3039 - 3043
反应条件
hydrogenchloride in tetrahydrofuran; water
T=20°C; 4 h;
参考文献
Panunzio, Mauro; Tamanini, Emiliano; Bandini, Elisa; Campana, Eileen; D'Aurizio, Antonio; Vicennati, Paola
Tetrahedron, 2006 , vol. 62, # 52 p. 12270 - 12280
反应条件
1: LiHMDS / tetrahydrofuran / 0 - 20 °C
2: Ph2SiH2 / RhH(CO)(PPh3)3 / tetrahydrofuran / 15 h / 20 °C
3: HCl / H2O; tetrahydrofuran / 4 h / 20 °C
View Scheme
参考文献
Panunzio, Mauro; Tamanini, Emiliano; Bandini, Elisa; Campana, Eileen; D'Aurizio, Antonio; Vicennati, Paola
Tetrahedron, 2006 , vol. 62, # 52 p. 12270 - 12280
