(R)-3-甲基氨基-1-(2-噻吩基)-1-丙醇合成路线 （共 22 条）
反应条件
1: Ph2SiH2 / RhH(CO)(PPh3)3 / tetrahydrofuran / 15 h / 20 °C
2: HCl / H2O; tetrahydrofuran / 4 h / 20 °C
View Scheme
参考文献
Panunzio, Mauro; Tamanini, Emiliano; Bandini, Elisa; Campana, Eileen; D'Aurizio, Antonio; Vicennati, Paola
Tetrahedron, 2006 , vol. 62, # 52 p. 12270 - 12280
反应条件
1: 54 percent / BF3*Et2O / CH2Cl2 / -78 - 20 °C
2: aluminum amalgam / propan-2-ol
3: LiHMDS / tetrahydrofuran / 0 - 20 °C
4: Ph2SiH2 / RhH(CO)(PPh3)3 / tetrahydrofuran / 15 h / 20 °C
5: HCl / H2O; tetrahydrofuran / 4 h / 20 °C
View Scheme
参考文献
Panunzio, Mauro; Tamanini, Emiliano; Bandini, Elisa; Campana, Eileen; D'Aurizio, Antonio; Vicennati, Paola
Tetrahedron, 2006 , vol. 62, # 52 p. 12270 - 12280
反应条件
1: aluminum amalgam / propan-2-ol
2: LiHMDS / tetrahydrofuran / 0 - 20 °C
3: Ph2SiH2 / RhH(CO)(PPh3)3 / tetrahydrofuran / 15 h / 20 °C
4: HCl / H2O; tetrahydrofuran / 4 h / 20 °C
View Scheme
参考文献
Panunzio, Mauro; Tamanini, Emiliano; Bandini, Elisa; Campana, Eileen; D'Aurizio, Antonio; Vicennati, Paola
Tetrahedron, 2006 , vol. 62, # 52 p. 12270 - 12280
反应条件
1: sodium hydrogen carbonate / CH2Cl2; H2O / 2 h / 20 °C
2: lithium aluminum hydride / tetrahydrofuran / 2 h / Heating
View Scheme
参考文献
Wang, Guangyin; Liu, Xingshun; Zhao, Gang
Tetrahedron Asymmetry, 2005 , vol. 16, # 10 p. 1873 - 1879
反应条件
1: 43 percent / immobilised lipase from Pseudomonas cepacia; phosphate buffer / diisopropyl ether / 14 h / pH 7.2
2: BH3*Me2S / tetrahydrofuran / 2 h / Heating
3: K2CO3 / CH2Cl2; tetrahydrofuran / 0.5 h / 20 °C
4: 88 percent / LAH / tetrahydrofuran / 1.5 h / Heating
View Scheme
参考文献
Kamal, Ahmed; Khanna, G. B. Ramesh; Ramu; Krishnaji
Tetrahedron Letters, 2003 , vol. 44, # 25 p. 4783 - 4787
反应条件
1: BH3*Me2S / tetrahydrofuran / 2 h / Heating
2: K2CO3 / CH2Cl2; tetrahydrofuran / 0.5 h / 20 °C
3: 88 percent / LAH / tetrahydrofuran / 1.5 h / Heating
View Scheme
参考文献
Kamal, Ahmed; Khanna, G. B. Ramesh; Ramu; Krishnaji
Tetrahedron Letters, 2003 , vol. 44, # 25 p. 4783 - 4787
反应条件
1: 3-chloro-1-(thiophen-2-yl)propan-1-one With sodium hydroxide; D-glucose; mannose in water
T=30°C; pH=6.0; 2 - 8 h;
2: methylamine in water
T=60°C; pH=6.0; 6 h;
参考文献
BASF AKTIENGESELLSCHAFT
Patent: WO2005/33094 A2, 2005 ;
Location in patent: Page/Page column 43-44 ;
反应条件
1: borane-dimethylsulfide complex; polymer-supported chiral sulfonamide / tetrahydrofuran / Heating
2: sodium hydrogen carbonate / CH2Cl2; H2O / 2 h / 20 °C
3: lithium aluminum hydride / tetrahydrofuran / 2 h / Heating
View Scheme
参考文献
Wang, Guangyin; Liu, Xingshun; Zhao, Gang
Tetrahedron Asymmetry, 2005 , vol. 16, # 10 p. 1873 - 1879
反应条件
1: 90 percent / NaBH4 / methanol / 0.5 h / 20 °C
2: 77 percent / methanol; H2O / 4 h / 20 °C
3: 43 percent / immobilised lipase from Pseudomonas cepacia; phosphate buffer / diisopropyl ether / 14 h / pH 7.2
4: BH3*Me2S / tetrahydrofuran / 2 h / Heating
5: K2CO3 / CH2Cl2; tetrahydrofuran / 0.5 h / 20 °C
6: 88 percent / LAH / tetrahydrofuran / 1.5 h / Heating
View Scheme
参考文献
Kamal, Ahmed; Khanna, G. B. Ramesh; Ramu; Krishnaji
Tetrahedron Letters, 2003 , vol. 44, # 25 p. 4783 - 4787
反应条件
1: 77 percent / methanol; H2O / 4 h / 20 °C
2: 43 percent / immobilised lipase from Pseudomonas cepacia; phosphate buffer / diisopropyl ether / 14 h / pH 7.2
3: BH3*Me2S / tetrahydrofuran / 2 h / Heating
4: K2CO3 / CH2Cl2; tetrahydrofuran / 0.5 h / 20 °C
5: 88 percent / LAH / tetrahydrofuran / 1.5 h / Heating
View Scheme
参考文献
Kamal, Ahmed; Khanna, G. B. Ramesh; Ramu; Krishnaji
Tetrahedron Letters, 2003 , vol. 44, # 25 p. 4783 - 4787
