1: BH3*Me2S / tetrahydrofuran / 2 h / Heating 2: K2CO3 / CH2Cl2; tetrahydrofuran / 0.5 h / 20 °C 3: 88 percent / LAH / tetrahydrofuran / 1.5 h / Heating View Scheme

1: (η5-C5Ph5)Ru(CO)2Cl; potassium tert-butylate; sodium carbonate / tetrahydrofuran; toluene / 0.08 h / 80 °C / Inert atmosphere 2: Candida antarctica lipase B-W104A; sodium carbonate / toluene / 24 h / 50 °C / Inert atmosphere; Resolution of racemate; Enzymatic reaction 3: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 80 °C 4: sodium hydrogencarbonate / dichloromethane; water / 1 h 5: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / Reflux View Scheme