2-羟基-6-三氟甲基烟腈合成路线 （共 4 条）
反应条件
potassium carbonate in toluene 9 h; Dean-StarkReflux;
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 19 p. 8392 - 8408,17
Journal of Medicinal Chemistry, , vol. 55, # 19 p. 8392 - 8408
反应条件
hydrogenchloride; sodium ethanolate in ethanol Heating;
参考文献
Helvetica Chimica Acta, , vol. 71, # 3 p. 596 - 601
反应条件
phosphorus pentachloride; trichlorophosphate 22 h; Reflux;
参考文献
US2013/79373 A1, ;
Paragraph 0265; 0268 ;
反应条件
1: trichlorophosphate; phosphorus pentachloride / 22 h / |Reflux
2: ammonia; hydrogen / isopropyl alcohol / 80 °C / 7500.75 Torr
View Scheme
参考文献
GRÜNENTHAL GMBH; FRANK, Robert; BAHRENBERG, Gregor; CHRISTOPH, Thomas; LESCH, Bernhard; LEE, Jeewoo
Patent: WO2013/45452 A1, 2013 ;
