1-苯基-3-(4-苯基苯基)苯合成路线 （共 21 条）
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in water; N,N-dimethyl-formamide
T=0°C; Suzuki-Miyaura Coupling; 5 h; Inert atmosphere;
参考文献
Lima, Carlos F. R. A. C.; Rodrigues, Ana S. M. C.; Silva, Vera L. M.; Silva, Artur M. S.; Santos, Luis M. N. B. F.
ChemCatChem, 2014 , vol. 6, # 5 p. 1291 - 1302
反应条件
bis(acetylacetonate)nickel(II) in diethyl ether; benzene
1.) 0 deg C, 1 h 2.) reflux, 3 h;
参考文献
Ibuki; Ozasa; Fujioka; et al.
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 7 p. 2369 - 2379
反应条件
copper
1.) 265-270 deg C, 2 h; 2.) 270-275 deg C, 0.5 h;
参考文献
Ozasa; Fujioka; Tsukada; Ibuki
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 2 p. 344 - 355
反应条件
copper
1.) 265-270 deg C, 2 h; 2.) 270-275 deg C, 0.5 h;
参考文献
Ozasa; Fujioka; Tsukada; Ibuki
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 2 p. 344 - 355
反应条件
oxalic acid in 1,4-dioxane
6 h; Heating; Yield given;
参考文献
Mochiike; Sakamoto; Hoshita
Chemical and pharmaceutical bulletin, 1983 , vol. 31, # 11 p. 3994 - 4000
反应条件
1: 22 percent / copper powder / 1 h / 240 °C
2: 98 percent / iron (activated) / benzene / Heating
3: 1.) NaNO2, conc. H2SO4; 2.) KI / 1.) water, 0-5 deg C, 2 h; 2.) water, 0-5 deg C
4: 147 mg / copper powder / 1.) 265-270 deg C, 2 h; 2.) 270-275 deg C, 0.5 h
View Scheme
参考文献
Ozasa; Fujioka; Tsukada; Ibuki
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 2 p. 344 - 355
反应条件
1: 98 percent / iron (activated) / benzene / Heating
2: 1.) NaNO2, conc. H2SO4; 2.) KI / 1.) water, 0-5 deg C, 2 h; 2.) water, 0-5 deg C
3: 147 mg / copper powder / 1.) 265-270 deg C, 2 h; 2.) 270-275 deg C, 0.5 h
View Scheme
参考文献
Ozasa; Fujioka; Tsukada; Ibuki
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 2 p. 344 - 355
反应条件
1: 94 percent / iron (activated) / benzene / Heating
2: 1.) NaNO2, conc. H2SO4; 2.) KI / 1.) water, 0-5 deg C, 2 h; 2.) water, 0-5 deg C
3: 150 mg / copper powder / 1.) 265-270 deg C, 2 h; 2.) 270-275 deg C, 0.5 h
View Scheme
参考文献
Ozasa; Fujioka; Tsukada; Ibuki
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 2 p. 344 - 355
反应条件
1: 2.1 g / copper powder / dimethylformamide / 20 h / Heating
2: 95 percent / activated iron / benzene
3: 1.) sodium nitrite, conc. H2SO4; 2.) potassium iodide / 1.) water, 0-5 deg C, 1.5 h; 2.) water, to 80 deg C
4: 269 mg / copper powder / 265 - 270 °C
View Scheme
参考文献
Ozasa, Shigeru; Fujioka, Yasuhiro; Fujiwara, Michiko; Ibuki, Eiichi
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 11 p. 3210 - 3222
反应条件
1: diethyl ether / rt., 24 h, then reflux, 2 h
2: oxalic acid / dioxane / 6 h / Heating
View Scheme
参考文献
Mochiike; Sakamoto; Hoshita
Chemical and pharmaceutical bulletin, 1983 , vol. 31, # 11 p. 3994 - 4000
