3,3-二(甲硫基)-1-[3-(三氟甲基)苯基]丙-2-烯-1-酮合成路线 (共 2 条)
反应条件
1: carbon disulfide; 3-(trifluoromethyl)acetophenone With potassium tert-butylate in tetrahydrofuran T=0 - 20°C; 0.5 h; 2: methyl iodide in tetrahydrofuran T=20°C; 0.5 h;
参考文献
BANYU PHARMACEUTICAL CO., LTD.
Patent: EP1566384 A1, 2005 ;
Location in patent: Page/Page column 44 ;
EP 1566384 A1
反应条件
sodium hydride 1.) DMSO, r.t., 3 h; 2.) DMSO, r.t., 2 h; Yield given. Multistep reaction;
参考文献
Perjessy, A.; Rudorf, W.-D.; Loos, D.; Sustekova, Z.
Monatshefte fuer Chemie, 1994 , vol. 125, # 12 p. 1389 - 1396