(2R)-2-BOC-氨基-3-苯磺酰-1-(2-四水吡喃基氧基)丙烷合成路线 （共 21 条）
反应条件
1: 1.) n-BuLi / 1.) THF, -78 deg C; 2.) -50 deg C, 2 h 2: 93 percent / PyH*OTs / ethanol / 6 h / 60 °C 3: 92 percent / 6percent Na-Hg, Na2HPO4 / methanol / 24 h / 25 °C 4: 78 percent / pyridinium dichromate / dimethylformamide / 6 h / 25 °C View Scheme
参考文献
Sasaki, N.Andre; Hashimoto, Chiyomi; Potier, Pierre
Tetrahedron Letters, 1987 , vol. 28, # 48 p. 6069 - 6072
反应条件
1: 1) n-BuLi / 1) THF, -78 deg C, 15 min, 2) THF, -78 to -10 deg C 2: 90 percent / t-BuOK / dimethylformamide / 2 h / Ambient temperature 3: 6percent Na-Hg, Na2HPO4 / methanol / 3 h / 0 - 20 °C 4: PPTS, EtOH / 6 h / 50 °C View Scheme
参考文献
Pauly, Regine; Sasaki, N. Andre; Potier, Pierre
Tetrahedron Letters, 1994 , vol. 35, # 2 p. 237 - 240
反应条件
1: n-BuLi / tetrahydrofuran / -78 - 20 °C 2: 6percent Na-Hg, Na2HPO4 / methanol / 3 h / 0 - 20 °C 3: PPTS / ethanol / 6 h / 50 °C 4: CrO3, H2SO4 / 1 h / 0 - 20 °C View Scheme
参考文献
Pauly, Regine; Sasaki, N. Andre; Potier, Pierre
Tetrahedron Letters, 1994 , vol. 35, # 2 p. 237 - 240
反应条件
1: 1) n-BuLi / 1) THF, -78 deg C, 15 min, 2) THF, RT, overnight 2: 85 percent / 6percent Na-Hg, Na2HPO4 / methanol / 3 h / 0 - 20 °C 3: PPTS, EtOH / 6 h / 50 °C 4: CrO3, H2SO4 / 1 h / 0 - 20 °C View Scheme
参考文献
Pauly, Regine; Sasaki, N. Andre; Potier, Pierre
Tetrahedron Letters, 1994 , vol. 35, # 2 p. 237 - 240
反应条件
1: 1) n-BuLi / 1) THF, -78 deg C, 15 min, 2) THF, -78 to -10 deg C 2: n-BuLi / tetrahydrofuran / -40 °C 3: 6percent Na-Hg, Na2HPO4 / methanol / 3 h / 0 - 20 °C 4: PPTS / ethanol / 6 h / 50 °C 5: CrO3, H2SO4 / 1 h / 0 - 20 °C View Scheme
参考文献
Pauly, Regine; Sasaki, N. Andre; Potier, Pierre
Tetrahedron Letters, 1994 , vol. 35, # 2 p. 237 - 240
反应条件
multistep reaction; var. α,ω-chlorobromoalkane; Product distribution;
参考文献
Pauly, Regine; Sasaki, N. Andre; Potier, Pierre
Tetrahedron Letters, 1994 , vol. 35, # 2 p. 237 - 240
反应条件
1: 1.) n-BuLi / 1.) THF, -78 deg C; 2.) -50 deg C, 2 h 2: PyH*OTS / ethanol / 6 h / 60 °C 3: 6 percent Na-Hg, Na2HPO4 / ethanol / 24 h / 25 °C View Scheme
参考文献
Sasaki, N.Andre; Hashimoto, Chiyomi; Potier, Pierre
Tetrahedron Letters, 1987 , vol. 28, # 48 p. 6069 - 6072
反应条件
1: 1) n-BuLi / 1) THF, -78 deg C, 15 min, 2) THF, -78 to -10 deg C 2: 90 percent / t-BuOK / dimethylformamide / 2 h / Ambient temperature 3: 6percent Na-Hg, Na2HPO4 / methanol / 3 h / 0 - 20 °C 4: PPTS, EtOH / 6 h / 50 °C 5: CrO3, H2SO4 / 1 h / 0 - 20 °C View Scheme
参考文献
Pauly, Regine; Sasaki, N. Andre; Potier, Pierre
Tetrahedron Letters, 1994 , vol. 35, # 2 p. 237 - 240
反应条件
multistep reaction; var. α,ω-chlorobromoalkane; Product distribution;
参考文献
Pauly, Regine; Sasaki, N. Andre; Potier, Pierre
Tetrahedron Letters, 1994 , vol. 35, # 2 p. 237 - 240
反应条件
1: 1.) n-BuLi / 1.) THF, -78 deg C; 2.) -50 deg C, 2 h 2: PyH*OTS / ethanol / 6 h / 60 °C 3: 6 percent Na-Hg, Na2HPO4 / ethanol / 24 h / 25 °C View Scheme
参考文献
Sasaki, N.Andre; Hashimoto, Chiyomi; Potier, Pierre
Tetrahedron Letters, 1987 , vol. 28, # 48 p. 6069 - 6072
