(R)-4-(4-羟基丁基)-2,2-二甲基噁唑啉-3-羧酸叔丁酯合成路线 （共 2 条）
反应条件
(1S)-10-camphorsulfonate in acetone T=21°C; 19 h; Inert atmosphere;
参考文献
Eisai RandD Management Co., Ltd.
Patent: EP2226325 A1, 2010 ;
Location in patent: Page/Page column 21-22 ;
反应条件
1: tert-butyl (4S)-4-(4-hydroxybutyl)-2,2-dimethyl-1,3-oxazolidine-3-carboxylate With potassium tert-butylate in tetrahydrofuran T=-12°C; Inert atmosphere; 2: benzyl bromide in tetrahydrofuran T=-12°C;
参考文献
Eisai RandD Management Co., Ltd.
Patent: EP2226325 A1, 2010 ;
Location in patent: Page/Page column 22 ;
