1: 65 percent / diphenyl phosphorazidate (DPPA), NEt3 / dimethylformamide / 1.) 0 deg C, 1 h, 2.) 20 deg C, 12 h 2: 82 percent / 1 N HCl / ethyl acetate / 1 h / 80 °C View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '11342940', constants.ctx, '0')">sodium hydroxide</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098229', constants.ctx, '0')">methanol</a> <br />T=100&deg;C;&nbsp;1&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 74 percent / tetrahydrofuran / 1 h / 70 &deg;C<br />2: 75 percent / 5 N NaOH / methanol / 1 h / 100 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 69 percent / ethanol; H₂O / 5 h / 80 &deg;C<br />2: 74 percent / tetrahydrofuran / 1 h / 70 &deg;C<br />3: 75 percent / 5 N NaOH / methanol / 1 h / 100 &deg;C<br /> <br /> &nbsp;