反应条件
1: sulfuric acid / 1.5 h / Heating
2: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 5 °C
3: triethylamine / chloroform / 0 - 20 °C
4: tetrachloromethane; polystyrene-triphosphine resin / 0.5 h / Heating
5: tetrahydrofuran / 1.5 h / Heating
6: hydrogenchloride / ethanol / 0.67 h / 110 °C / microwave irradiation
View Scheme
参考文献
Tavares, Francis X.; Al-Barazanji, Kamal A.; Bishop, Michael J.; Britt, Christy S.; Carlton, David L.; Cooper, Joel P.; Feldman, Paul L.; Garrido, Dulce M.; Goetz, Aaron S.; Grizzle, Mary K.; Hertzog, Donald L.; Ignar, Diane M.; Lang, Daniel G.; McIntyre, Maggie S.; Ott, Ronda J.; Peat, Andrew J.; Zhou, Hui-Qiang
Journal of Medicinal Chemistry, 2006 , vol. 49, # 24 p. 7108 - 7118