6-氯-1H-吡咯并[2,3-B]吡啶-4-羧酸合成路线 （共 2 条）
反应条件
1: With water; lithium hydroxide hydrate in methanol T=20°C; 2.5 h; 2: With hydrogenchloride in methanol; water 0.5 h;
参考文献
SANOFI-AVENTIS
Patent: US2011/184015 A1, 2011 ;
Location in patent: Page/Page column 24 ;
反应条件
1.1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 1.08 h / -5 °C / Inert atmosphere 2.1: methanesulfonyl chloride / N,N-dimethyl-formamide / 2 h / 25 - 80 °C 3.1: water; lithium hydroxide hydrate / methanol / 2.5 h / 20 °C 3.2: 0.5 h View Scheme
参考文献
SANOFI-AVENTIS
Patent: US2011/184015 A1, 2011 ;
