1-(1-三苯甲基-4-)乙酮合成路线 （共 7 条）
反应条件
manganese(IV) oxide in 1,4-dioxane T=0°C; 2 h; Heating / reflux;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/4096 A1, 2008 ;
Location in patent: Page/Page column 79-80 ;
反应条件
triethylamine in N,N-dimethyl-formamide T=20°C; 2 h;
参考文献
Genentech, Inc.
Patent: US2012/214762 A1, 2012 ;
Location in patent: Page/Page column 113 ;
反应条件
potassium hydroxide in ethanol; water 10 h; Heating; Yield given;
参考文献
Lipp; Arrang; Garbarg; Luger; Schwartz; Schunack
Journal of Medicinal Chemistry, 1992 , vol. 35, # 23 p. 4434 - 4441
反应条件
1: 98 percent / tetrahydrofuran; diethyl ether / 1 h 2: 85 percent / manganese(IV) oxide / CH2Cl2 / 12 h / 20 °C View Scheme
参考文献
Matsunaga, Nobuyuki; Kaku, Tomohiro; Itoh, Fumio; Tanaka, Toshimasa; Hara, Takahito; Miki, Hiroshi; Iwasaki, Masahiko; Aono, Tetsuya; Yamaoka, Masuo; Kusaka, Masami; Tasaka, Akihiro
Bioorganic and medicinal chemistry, 2004 , vol. 12, # 9 p. 2251 - 2273
反应条件
1: tetrahydrofuran 2: CF3COOH / 1 h / Heating View Scheme
参考文献
Cordi; Snyers; Giraud-Mangin; Van der Maesen; Van Hoeck; Beuze; Ellens; Napora; Gillet; Gorissen; Calderon; Remacle; Janssens de Varebeke; Van Dorsser; Roba
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 7 p. 557 - 568
反应条件
trifluoroacetic acid 1 h; Heating;
参考文献
Cordi; Snyers; Giraud-Mangin; Van der Maesen; Van Hoeck; Beuze; Ellens; Napora; Gillet; Gorissen; Calderon; Remacle; Janssens de Varebeke; Van Dorsser; Roba
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 7 p. 557 - 568
反应条件
1: CF3COOH / 1 h / Heating 2: H2 / 10percent Pd/C / ethanol / 6 h / 70 °C / 2040.2 Torr View Scheme
参考文献
Cordi; Snyers; Giraud-Mangin; Van der Maesen; Van Hoeck; Beuze; Ellens; Napora; Gillet; Gorissen; Calderon; Remacle; Janssens de Varebeke; Van Dorsser; Roba
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 7 p. 557 - 568
