(R)-1-(3-氯苯基)-1-丙胺盐酸盐合成路线 （共 3 条）
反应条件
hydrogenchloride in 1,4-dioxane; methanol T=20°C; 0.5 - 0.75 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2009/83526 A1, 2009 ;
Location in patent: Page/Page column 63 ;
WO 2009/083526 A1
反应条件
hydrogenchloride in 1,4-dioxane; methanol T=20°C; 0.666667 h;
参考文献
Mori, Yutaka; Ogawa, Yasuyuki; Mochizuki, Akiyoshi; Nakamura, Yuji; Fujimoto, Teppei; Sugita, Chie; Miyazaki, Shojiro; Tamaki, Kazuhiko; Nagayama, Takahiro; Nagai, Yoko; Inoue, Shin-Ichi; Chiba, Katsuyoshi; Nishi, Takahide
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 18 p. 5907 - 5922
反应条件
1: titanium tetraethoxide / tetrahydrofuran / 5.5 h / 70 °C 2: L-Selectridereg; / tetrahydrofuran / 1.08 h / |Cooling with ice 3: hydrogenchloride / methanol; 1,4-dioxane / 0.67 h / 20 °C View Scheme
参考文献
Mori, Yutaka; Ogawa, Yasuyuki; Mochizuki, Akiyoshi; Nakamura, Yuji; Fujimoto, Teppei; Sugita, Chie; Miyazaki, Shojiro; Tamaki, Kazuhiko; Nagayama, Takahiro; Nagai, Yoko; Inoue, Shin-Ichi; Chiba, Katsuyoshi; Nishi, Takahide
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 18 p. 5907 - 5922
