N-BOC-3-氯丙基胺合成路线 （共 11 条）
反应条件
sodium hydrogencarbonate; sodium chloride in chloroform; water 1.5 h; Heating;
参考文献
Chen, Yulong; White, Emil H.
Organic Preparations and Procedures International, 1996 , vol. 28, # 1 p. 65 - 76
反应条件
triethylamine in dichloromethane T=0°C;
参考文献
Wen, Liping; Liu, Qian; Ma, Jie; Tian, Ye; Li, Cuihong; Bo, Zhishan; Jiang, Lei
Advanced Materials, 2012 , vol. 24, # 46 p. 6193 - 6198
反应条件
1: 3-amino-propan-1-ol With thionyl chloride in toluene 2 h; Cooling with iceReflux; 2: With triethylamine in water T=20°C; 0.5 h; 3: di-tert-butyl dicarbonate in tetrahydrofuran; water T=20°C; 18 h;
参考文献
GIULIANI S.P.A.; GIULIANI, Giammaria; PAUS, Ralf; BENEDUSI, Anna; MARZANI, Barbara; BARONI, Sergio
Patent: WO2014/16407 A1, 2014 ;
Location in patent: Page/Page column 7-8 ;
反应条件
triethylamine in dichloromethane T=0 - 20°C; Inert atmosphere;
参考文献
Hallett, Andrew J.; Christian, Paul; Jones, Jennifer E.; Pope, Simon J. A.
Chemical Communications, 2009 , # 28 p. 4278 - 4280
反应条件
methanesulfonyl chloride; triethylamine in DCM
参考文献
WO2007/71396 A2, ;
Page/Page column 134 ;
WO 2007/071396 A2
反应条件
triethylamine in 1,4-dioxane; water 6 h; Ambient temperature;
参考文献
Tanaka, Ken-Ichi; Yoshifuji, Shigeyuki; Nitta, Yoshihiro
Chemical & Pharmaceutical Bulletin, 1988 , vol. 36, # 8 p. 3125 - 3129
反应条件
in 1,4-dioxane; water
反应条件
1: 81 percent / KI, Aliquat 336, NaN3 / CH2Cl2 / 8 h / 110 °C 2: 86 percent / H2 / Pd/C (5percent) / ethanol / 8 h / 1125.09 Torr View Scheme
参考文献
Benz, Herbert; Hesse, Manfred
Helvetica Chimica Acta, 1993 , vol. 76, # 4 p. 1636 - 1648
反应条件
1: 74 percent / 18-crown-6 / acetonitrile / 14 h / Heating 2: 74 percent / NaBH4, cobaltous chloride hexahydrate / methanol / 1 h / 0 °C View Scheme
参考文献
Benz, Herbert; Hesse, Manfred
Helvetica Chimica Acta, 1993 , vol. 76, # 4 p. 1636 - 1648
反应条件
1: 63 percent / NaH / tetrahydrofuran / Ambient temperature 2: (-)-sparteine, n-BuLi / diethyl ether; cyclohexane / 1.) -78 deg C, 2 h, 2.) -25 deg C, 1 h 3: 10 percent / sodium metaperiodate, RuCl3 hydrate / CCl4; acetonitrile; H2O / 2 h / Ambient temperature View Scheme
参考文献
Serino; Stehle; Yong Sun Park; Florio; Beak
Journal of Organic Chemistry, 1999 , vol. 64, # 4 p. 1160 - 1165
