1: pyridine / 16 h / 20 °C 2: potassium ethanolate / ethanol; benzene / 5 h / 0 °C / |Inert atmosphere 3: sodium tetrahydroborate / methanol / 3 h / 20 °C 4: sodium hydroxide / dichloromethane / 3 h / 0 - 20 °C 5: sodium hydride / tetrahydrofuran; acetonitrile; mineral oil 6: lithium aluminium tetrahydride / 5 °C / |Reflux 7: 5 palladium on charcoal; hydrogen / methanol / 16 h 8: CHIRALPAK AD-H column / |Resolution of racemate 9: 1H-imidazole / dichloromethane / 16 h / 0 - 5 °C 10: potassium carbonate / N,N-dimethyl-formamide / 2 h / 55 °C 11: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 25 °C View Scheme

1: pyridine / 16 h / 20 °C 2: potassium ethanolate / ethanol; benzene / 5 h / 0 °C / |Inert atmosphere 3: sodium tetrahydroborate / methanol / 3 h / 20 °C 4: sodium hydroxide / dichloromethane / 3 h / 0 - 20 °C 5: sodium hydride / tetrahydrofuran; acetonitrile; mineral oil 6: lithium aluminium tetrahydride / 5 °C / |Reflux 7: 5 palladium on charcoal; hydrogen / methanol / 16 h 8: CHIRALPAK AD-H column / |Resolution of racemate 9: 1H-imidazole / dichloromethane / 16 h / 0 - 5 °C 10: pyridine / 3 h / 0 - 25 °C View Scheme