(2Z)-1-[5,6-二氢-3-(三氟甲基)-1,2,4-三唑并[4,3-a]吡嗪-7(8H)-基]-3-[[(1R)-1-苯乙基]氨基]-4-(2,4,5-三氟苯基)-2-丁烯-1-酮合成路线 (共 5 条)
反应条件
acetic acid in isopropyl alcohol T=40°C;
参考文献
DR. REDDY'S LABORATORIES LIMITED; DR. REDDY'S LABORATORIES, INC.
Patent: WO2009/85990 A2, 2009 ;
Location in patent: Page/Page column 29 ;
反应条件
1.1: 4-(N,N-dimethlyamino)pyridine; N-ethyl-N,N-diisopropylamine / acetonitrile / 50 °C 1.2: 3.75 h / 50 °C 1.3: 6 h / 55 °C 2.1: acetic acid / 5 h / Reflux View Scheme
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.; BANDICHHOR, Rakeshwar; GUDIMALLA, Nagaraju; DWIVEDI, Namrata; CHETLURU, Kiran Kumar; GADE, Srinivas Reddy; MUVVA, Venkateswarlu; SRIVASTAVA, Bindu
Patent: WO2011/25932 A2, 2011 ;
反应条件
1: 4-methyl-morpholine / ethyl acetate / 6 h / Reflux 2: acetic acid / 5 h / Reflux View Scheme
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.; BANDICHHOR, Rakeshwar; GUDIMALLA, Nagaraju; DWIVEDI, Namrata; CHETLURU, Kiran Kumar; GADE, Srinivas Reddy; MUVVA, Venkateswarlu; SRIVASTAVA, Bindu
Patent: WO2011/25932 A2, 2011 ;
反应条件
1: sodium tetrahydroborate; formic acid / tetrahydrofuran / -30 °C 2: 20 palladium(II) hydroxide on carbon; hydrogen; acetic acid / methanol; water / 14 h / 50 °C / 7500.75 Torr 3: phosphoric acid; water / isopropyl alcohol / 20 - 75 °C View Scheme
参考文献
Lin, Kuaile; Cai, Zhengyan; Zhou, Weicheng
Synthetic Communications, 2013 , vol. 43, # 24 p. 3281 - 3286
反应条件
1: sodium tetrahydroborate; formic acid / tetrahydrofuran / -30 °C
2: 20 palladium(II) hydroxide on carbon; hydrogen; acetic acid / methanol; water / 14 h / 50 °C / 7500.75 Torr
View Scheme
参考文献
Lin, Kuaile; Cai, Zhengyan; Zhou, Weicheng
Synthetic Communications, 2013 , vol. 43, # 24 p. 3281 - 3286