反应条件
1: DMAP / CH2Cl2 / 16 h 2: 1.) HBr/HOAc (33percent), 2.) NaHCO3 / 1.) 4 h, room temperature, 2.) H2O, ethyl acetate, 24 h, room temperature 3: 1.) N,N'-carbonyldiimidazole / 1.) CH2Cl2, 1 h, room temperature, 2.) CH2Cl2, 8 h 4: 83 percent / H2 / 10percent Pd/C / ethanol / 4 h / Ambient temperature View Scheme
参考文献
Sharma, Sushil K.; Miller, Marvin J.; Payne, Shelley M.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 2 p. 357 - 367
