lithium salt of proline; tetrabutylammomium bromide; potassium hydroxide; copper dichloride in water
T=120°C; 0.666667 h; Microwave irradiationGreen chemistry;
1: methanol / 1 h / Heating
2: H2 / 10percent Pd/C / tetrahydrofuran / 4 h / 760 Torr
3: pyridine, DMAP / tetrahydrofuran / 1 h
View Scheme
参考文献
Jones, Gordon H.; Venuti, Michael C.; Young, John M.; Murthy, D.V. Krishna; Loe, Brad E.; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1504 - 1511