N-苄氧羰基甘氨酰-L-苯丙氨酸合成路线 （共 69 条）
反应条件
1: (i) 1H,1'H-1,1'-carbonyl-bis-<1,2,4>triazole, DMF, (ii) /BRN= 2212290/ 2: (alkaline hydrolysis) View Scheme
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 80, p. 1372 - 1375
反应条件
(i) aq. KHCO3, THF, (ii) HCl; Multistep reaction;
参考文献
Justus Liebigs Annalen der Chemie, , vol. 698, p. 242 - 252
反应条件
(i) HCl, MeOH, (ii) N2H4*H2O; Multistep reaction;
参考文献
Slebioda, Marek; St-Amand, Marc A.; Chen, Francis M. F.; Benoiton, N. Leo
Canadian Journal of Chemistry, 1988 , vol. 66, p. 2540 - 2544
反应条件
1-hydroxy-pyrrolidine-2,5-dione; triethylamine in dichloromethane; N,N-dimethyl-formamide T=20°C;
参考文献
Hackel; Hinz; Hedwig
Physical Chemistry Chemical Physics, 2000 , vol. 2, # 21 p. 4843 - 4849
反应条件
1-hydroxy-pyrrolidine-2,5-dione; triethylamine; dicyclohexyl-carbodiimide in dichloromethane; N,N-dimethyl-formamide T=20°C;
参考文献
Hackel; Hinz; Hedwig
Physical Chemistry Chemical Physics, 2000 , vol. 2, # 21 p. 4843 - 4849
反应条件
potassium carbonate in dichloromethane 8 h; Ambient temperature;
参考文献
Nakata, Takashi; Nakatani, Masaru; Takahashi, Masatoshi; Okai, Jiro; Kawaoka, Yoshiaki; Kouge, Katsushige; Okai, Hideo
Bulletin of the Chemical Society of Japan, 1996 , vol. 69, # 4 p. 1099 - 1106
反应条件
methanol; palladium; acetic acid Hydrogenation;
参考文献
Kapoor; Davis; Graetzer
Journal of pharmaceutical sciences, 1968 , vol. 57, # 9 p. 1514 - 1519
反应条件
1: tributylphosphine / acetonitrile / 1 h / 27 °C 2: N-methylmorpholine N-oxide monohydrate (NMMNO) / acetonitrile; H2O / 15 h / Ambient temperature View Scheme
参考文献
Ghosh, Sunil Kumar; Singh, Usha; Chandha, Mohindra S.; Mamdapur, Vasant R.
Bulletin of the Chemical Society of Japan, 1993 , vol. 66, # 5 p. 1566 - 1568
参考文献
Miyazawa, Toshifumi; Ensatsu, Eiichi; Hiramatsu, Makoto; Yanagihara, Ryoji; Yamada, Takashi
Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 3 p. 396 - 401
