2-(乙酰基氨基)-5-噻唑羧酸合成路线 （共 2 条）
反应条件
1: With water; potassium hydroxide in methanol T=20°C; 2 h; 2: With hydrogenchloride in methanol; dichloromethane; water T=20°C; pH=3;
参考文献
TAKEDA SAN DIEGO, INC.; MATTSON, Matthew
Patent: WO2011/115758 A1, 2011 ;
Location in patent: Page/Page column 11 ;
反应条件
pyridine T=20 - 130°C;
参考文献
UCB PHARMA S.A.; ALI, Mezher, Hussein; BROWN, Julien, Alistair; DE CANDOLE, Benjamin, Charles; HUTCHINSON, Brian, Woodside; LANGHAM, Barry, John; NEUSS, Judi, Charlotte; QUINCEY, Joanna, Rachel; TREVITT, Graham, Peter
Patent: WO2010/146351 A1, 2010 ;
Location in patent: Page/Page column 44 ;
WO 2010/146351 A1
