4-Boc-6-氨基-1,4-噁氮杂烷合成路线 （共 4 条）
反应条件
hydrogen bromide; hydrogen in methanol; water T=20°C; P=3206.4 Torr; 144 h;
参考文献
WO2011/29046 A1, ;
Page/Page column 209; 210 ;
WO 2011/029046 A1
反应条件
1: osmium(VIII) oxide; sodium periodate / 1,4-dioxane; water; tert-butyl alcohol / 18 h / 20 °C 2: hydroxylamine hydrochloride; triethylamine / tetrahydrofuran / 20 °C 3: hydrogen; hydrogen bromide / water; methanol / 144 h / 20 °C / 3206.4 Torr View Scheme
参考文献
WO2011/29046 A1, ;
WO 2011/029046 A1
反应条件
1: hydroxylamine hydrochloride; triethylamine / tetrahydrofuran / 20 °C 2: hydrogen; hydrogen bromide / water; methanol / 144 h / 20 °C / 3206.4 Torr View Scheme
参考文献
WO2011/29046 A1, ;
WO 2011/029046 A1
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / Cooling with ice 1.2: 20 °C 2.1: osmium(VIII) oxide; sodium periodate / 1,4-dioxane; water; tert-butyl alcohol / 18 h / 20 °C 3.1: hydroxylamine hydrochloride; triethylamine / tetrahydrofuran / 20 °C 4.1: hydrogen; hydrogen bromide / water; methanol / 144 h / 20 °C / 3206.4 Torr View Scheme
参考文献
WO2011/29046 A1, ;
WO 2011/029046 A1
