反应条件
1: pyridine
2: 74 percent / (CF3CO)2O, H2O2, H2SO4 / -2 °C
3: 1.) (COCl)2, DMSO, 2.) Et3N / 1.) CH2Cl2, -50 deg C, 1 h, 2.) CH2Cl2, 25 deg C, 5 min
4: 75 percent / BuLi / tetrahydrofuran / 2 h / 0 °C
5: 81 percent / NaBH4 / ethanol / 25 °C
6: 85 percent / H2SO4 / CHCl3 / 0.08 h / 25 °C
7: 100 percent / KOH / ethanol / 2 h / 70 °C
View Scheme
参考文献
Ruan; Wilson; Schroepfer Jr.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 3 p. 233 - 236
