(2S)-1-[(2S)-6-氨基-2-(羟基-(4-苯基丁基)磷酰)氧基己酰]-2,3-二氢吲哚-2-羧酸合成路线 （共 7 条）
反应条件
hydrogen; palladium dihydroxide in methanol 2 h; Yield given;
参考文献
Karanewsky; Badia; Cushman; DeForrest; Dejneka; Lee; Loots; Petrillo
Journal of Medicinal Chemistry, 1990 , vol. 33, # 5 p. 1459 - 1469
反应条件
1: N,N'-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / Ambient temperature 2: NaIO4 / dioxane; H2O / 16 h / Ambient temperature 3: H2 / 20percent Pd(OH)2/C / methanol / 2 h View Scheme
参考文献
Karanewsky; Badia; Cushman; DeForrest; Dejneka; Lee; Loots; Petrillo
Journal of Medicinal Chemistry, 1990 , vol. 33, # 5 p. 1459 - 1469
反应条件
1: triethylamine, 4-(dimethylamino)pyridine / tetrahydrofuran / 16 h / Ambient temperature 2: 1.0 N LiOH / dioxane / 16 h / Ambient temperature 3: ethyl acetate / 1.5 h / Ambient temperature 4: N,N'-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / Ambient temperature 5: NaIO4 / dioxane; H2O / 16 h / Ambient temperature 6: H2 / 20percent Pd(OH)2/C / methanol / 2 h View Scheme
参考文献
Karanewsky; Badia; Cushman; DeForrest; Dejneka; Lee; Loots; Petrillo
Journal of Medicinal Chemistry, 1990 , vol. 33, # 5 p. 1459 - 1469
反应条件
1: triethylamine, 4-(dimethylamino)pyridine / tetrahydrofuran / 16 h / Ambient temperature 2: 1.0 N LiOH / dioxane / 16 h / Ambient temperature 3: ethyl acetate / 1.5 h / Ambient temperature 4: N,N'-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / Ambient temperature 5: NaIO4 / dioxane; H2O / 16 h / Ambient temperature 6: H2 / 20percent Pd(OH)2/C / methanol / 2 h View Scheme
参考文献
Karanewsky; Badia; Cushman; DeForrest; Dejneka; Lee; Loots; Petrillo
Journal of Medicinal Chemistry, 1990 , vol. 33, # 5 p. 1459 - 1469
反应条件
1: 1.0 N LiOH / dioxane / 16 h / Ambient temperature 2: ethyl acetate / 1.5 h / Ambient temperature 3: N,N'-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / Ambient temperature 4: NaIO4 / dioxane; H2O / 16 h / Ambient temperature 5: H2 / 20percent Pd(OH)2/C / methanol / 2 h View Scheme
参考文献
Karanewsky; Badia; Cushman; DeForrest; Dejneka; Lee; Loots; Petrillo
Journal of Medicinal Chemistry, 1990 , vol. 33, # 5 p. 1459 - 1469
反应条件
1: N,N'-dicyclohexylcarbodiimide, 4-(dimethylamino)pyridine / tetrahydrofuran / 2 h / Ambient temperature 2: NaIO4 / dioxane; H2O / 16 h / Ambient temperature 3: H2 / 20percent Pd(OH)2/C / methanol / 2 h View Scheme
参考文献
Karanewsky; Badia; Cushman; DeForrest; Dejneka; Lee; Loots; Petrillo
Journal of Medicinal Chemistry, 1990 , vol. 33, # 5 p. 1459 - 1469
反应条件
1: NaIO4 / dioxane; H2O / 16 h / Ambient temperature 2: H2 / 20percent Pd(OH)2/C / methanol / 2 h View Scheme
参考文献
Karanewsky; Badia; Cushman; DeForrest; Dejneka; Lee; Loots; Petrillo
Journal of Medicinal Chemistry, 1990 , vol. 33, # 5 p. 1459 - 1469
