1-(苯基)-1-(4-(2-(二乙基氨基)-乙氧基)苯基)-2-(4-羟基苯基)-2-氯乙烷合成路线 （共 4 条）
反应条件
hydrogen; palladium on activated charcoal in acetic acid P=1034.3 Torr; 2 h;
参考文献
Ruenitz, Peter C.; Arrendale, Richard F.; Schmidt, Walter F.; Thompson, Carolyn B.; Nanavati, Nitin T.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 1 p. 192 - 197
反应条件
1: 49 percent / 1) TiCl4, Zn / tetrahydrofuran / 1) reflux, 2 h, 2) r.t. 2: 65 percent / N-chlorosuccinimide / CHCl3 / 3 h / Heating 3: H2 / 10percent Pd/C / acetic acid / 2 h / 1034.3 Torr View Scheme
参考文献
Ruenitz, Peter C.; Arrendale, Richard F.; Schmidt, Walter F.; Thompson, Carolyn B.; Nanavati, Nitin T.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 1 p. 192 - 197
反应条件
1: 1) NaH / 1) DMF, 2) 125 deg C, 4 h 2: 49 percent / 1) TiCl4, Zn / tetrahydrofuran / 1) reflux, 2 h, 2) r.t. 3: 65 percent / N-chlorosuccinimide / CHCl3 / 3 h / Heating 4: H2 / 10percent Pd/C / acetic acid / 2 h / 1034.3 Torr View Scheme
参考文献
Ruenitz, Peter C.; Arrendale, Richard F.; Schmidt, Walter F.; Thompson, Carolyn B.; Nanavati, Nitin T.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 1 p. 192 - 197
反应条件
1: 65 percent / N-chlorosuccinimide / CHCl3 / 3 h / Heating 2: H2 / 10percent Pd/C / acetic acid / 2 h / 1034.3 Torr View Scheme
参考文献
Ruenitz, Peter C.; Arrendale, Richard F.; Schmidt, Walter F.; Thompson, Carolyn B.; Nanavati, Nitin T.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 1 p. 192 - 197
