(S)-2-(Boc-氨基)-4-(Fmoc-氨基)丁酸合成路线 （共 7 条）
参考文献
Galpin, deceased; Ian J.; Galpin, heir; by Christine M.
Patent: US5079341 A1, 1992 ;
反应条件
sodium hydrogencarbonate in 1,4-dioxane; water T=20°C; Acylation; 2 h;
参考文献
Yu, Chongxi; Taylor, John W.
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 1 p. 161 - 175
反应条件
sodium carbonate in 1,4-dioxane 1.) 0 deg C, 1 h; 2.) r.t., 22 h;
参考文献
Galpin; Mohammed; Patel
Tetrahedron, 1988 , vol. 44, # 6 p. 1773 - 1782
反应条件
sodium carbonate in 1,4-dioxane 1.) 1 h, 0 deg C, 2.) 2 h, 25 deg C;
参考文献
Ruan, Fuqiang; Chen, Yanqiu; Itoh, Katsumi; Sasaki, Tomikazu; Hopkins, Paul B.
Journal of Organic Chemistry, 1991 , vol. 56, # 14 p. 4347 - 4354
反应条件
1: 70.6 percent / bis(trifluoroacetoxy)-phenyliodine; N,N-diisopropylethylamine / acetonitrile; H2O / 20 °C 2: 79.5 percent / NaHCO3 / H2O; dioxane / 2 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 7, # 1 p. 161 - 175
反应条件
1: 94 percent / CuSO4, NaOH / H2O / 72 h / Ambient temperature 2: 50 percent / aq. Na2CO3 / dioxane / 1.) 0 deg C, 1 h; 2.) r.t., 22 h View Scheme
参考文献
Tetrahedron, , vol. 44, # 6 p. 1773 - 1782
反应条件
piperidine in N,N-dimethyl-formamide T=20°C; 0.5 h;
参考文献
FIBROGEN, INC.; HO, Wen-Bin; ZHAO, Hongda; DENG, Shaojiang; NG, Danny; WRIGHT, Lee R.; WU, Min; ZHOU, Xiaoti; AREND, Michael P.; FLIPPIN, Lee A.
Patent: WO2013/134660 A1, 2013 ;
Location in patent: Paragraph 0280 ;
