2’-O-(叔-丁基二甲基硅烷基)-5’-O-三苯甲基尿苷合成路线 （共 5 条）
反应条件
1: 71 percent / DMAP / acetonitrile / 20 h / Ambient temperature 2: AIBN, Bu3SnH / toluene / 3 h / 85 °C 3: TBAF / tetrahydrofuran / 4 h / 75 °C 4: 81 percent / ZnBr2 / CH2Cl2; methanol / 0.33 h View Scheme
参考文献
Lin, Tai-Shun; Yang, Jin-Hua; Liu, Mao-Chin; Shen, Zhi-Yi; Cheng, Yung-Chi; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 693 - 701
反应条件
1: 71 percent / DMAP / acetonitrile / 20 h / Ambient temperature 2: AIBN, Bu3SnH / toluene / 3 h / 85 °C 3: TBAF / tetrahydrofuran / 4 h / 75 °C 4: 81 percent / ZnBr2 / CH2Cl2; methanol / 0.33 h 5: 80 percent / pyridine / 20 h / Ambient temperature 6: 69 percent / o-chlorophenylphosphorodichloridate / pyridine / 48 h / Ambient temperature 7: 75 percent / NH4OH / dioxane / 2.5 h / Ambient temperature 8: 82 percent / NaOEt / 24 h / Ambient temperature 9: 77 percent / methanol / 4 h / Heating View Scheme
参考文献
Rhie; Pfleiderer
Nucleosides and Nucleotides, 1994 , vol. 13, # 6-7 p. 1425 - 1452
反应条件
1: 71 percent / DMAP / acetonitrile / 20 h / Ambient temperature
2: AIBN, Bu3SnH / toluene / 3 h / 85 °C
3: TBAF / tetrahydrofuran / 4 h / 75 °C
4: 81 percent / ZnBr2 / CH2Cl2; methanol / 0.33 h
5: 80 percent / pyridine / 20 h / Ambient temperature
6: 69 percent / o-chlorophenylphosphorodichloridate / pyridine / 48 h / Ambient temperature
7: 75 percent / NH4OH / dioxane / 2.5 h / Ambient temperature
8: 82 percent / NaOEt / 24 h / Ambient temperature
View Scheme
参考文献
Lin, Tai-Shun; Yang, Jin-Hua; Liu, Mao-Chin; Shen, Zhi-Yi; Cheng, Yung-Chi; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 693 - 701
反应条件
1: 71 percent / DMAP / acetonitrile / 20 h / Ambient temperature
2: AIBN, Bu3SnH / toluene / 3 h / 85 °C
3: TBAF / tetrahydrofuran / 4 h / 75 °C
4: 81 percent / ZnBr2 / CH2Cl2; methanol / 0.33 h
5: 80 percent / pyridine / 20 h / Ambient temperature
6: 69 percent / o-chlorophenylphosphorodichloridate / pyridine / 48 h / Ambient temperature
7: 75 percent / NH4OH / dioxane / 2.5 h / Ambient temperature
8: 82 percent / NaOEt / 24 h / Ambient temperature
9: 77 percent / methanol / 4 h / Heating
10: 78 percent / pyridine / 2 h
View Scheme
参考文献
Rhie; Pfleiderer
Nucleosides and Nucleotides, 1994 , vol. 13, # 6-7 p. 1425 - 1452
反应条件
Multi-step reaction with 2 steps 1: 71 percent / DMAP / acetonitrile / 20 h / Ambient temperature2: AIBN, Bu3SnH / toluene / 3 h / 85 °C
参考文献
Rhie; Pfleiderer Nucleosides and Nucleotides, 1994 , vol. 13, # 6-7 p. 1425 - 1452
