1: toluene-p-sulphonic acid / benzene / Heating 2: 75 percent / LDA / diethyl ether / 9 h / 20 °C View Scheme

<b>Multi-step reaction with 3 steps<br /> </b>1: 1.) THF, reflux, 1 h, 2.) THF, 20 deg C, reflux, 1 h<br />2: 80 percent / LiBr / diethyl ether / 20 &deg;C<br />3: 89 percent / sodium in ammonia, ammonium chloride / diethyl ether / 0.33 h<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 80 percent / LiBr / diethyl ether / 20 &deg;C<br />2: 89 percent / sodium in ammonia, ammonium chloride / diethyl ether / 0.33 h<br /> <br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1: triethylamine / diethyl ether<br />2: 1.) NaH / 1.) THF, reflux, 30 m, 2.) THF, 20 deg C, 16 h<br />3: 1.) THF, reflux, 1 h, 2.) THF, 20 deg C, reflux, 1 h<br />4: 80 percent / LiBr / diethyl ether / 20 &deg;C<br />5: 89 percent / sodium in ammonia, ammonium chloride / diethyl ether / 0.33 h<br /> <br /> &nbsp;