1: 61 percent / tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 1 h / Ambient temperature 2: 93 percent / pyridine / 24 h / 18 °C 3: pyridine / CH2Cl2 / 2 h / Ambient temperature 4: 60 percent / tributyltin hydride, α,α'-azobisisobutironitrile / toluene / 3 h / 70 °C 5: 1N NaOH / methanol / 5 h / Heating; pH = 9 View Scheme

1: 61 percent / tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 1 h / Ambient temperature 2: 93 percent / pyridine / 24 h / 18 °C 3: pyridine / CH2Cl2 / 2 h / Ambient temperature 4: 60 percent / tributyltin hydride, α,α'-azobisisobutironitrile / toluene / 3 h / 70 °C 5: 94 percent / 1N HCl / methanol / 0.5 h / Ambient temperature View Scheme

<b>Multi-step reaction with 3 steps<br /> </b>1: sodium bicarbonate / H₂O; diethyl ether / 16 h / 15 &deg;C<br />2: 4-dimethylaminopyridone / acetonitrile / 2 h / Ambient temperature<br />3: α,α'-azobisisobutyronitrile, tributyltin hydride / toluene / 4 h / 70 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 4-dimethylaminopyridone / acetonitrile / 2 h / Ambient temperature<br />2: α,α'-azobisisobutyronitrile, tributyltin hydride / toluene / 4 h / 70 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1: 68 percent / pyridine / 48 h / Ambient temperature<br />2: 73 percent / CrO₃, pyridine, Ac₂O / CH₂Cl₂ / 0.75 h / Ambient temperature<br />3: sodium bicarbonate / H₂O; diethyl ether / 16 h / 15 &deg;C<br />4: 4-dimethylaminopyridone / acetonitrile / 2 h / Ambient temperature<br />5: α,α'-azobisisobutyronitrile, tributyltin hydride / toluene / 4 h / 70 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1: 68 percent / pyridine / 48 h / Ambient temperature<br />2: 73 percent / CrO₃, pyridine, Ac₂O / CH₂Cl₂ / 0.75 h / Ambient temperature<br />3: sodium bicarbonate / H₂O; diethyl ether / 16 h / 15 &deg;C<br />4: 4-dimethylaminopyridone / acetonitrile / 2 h / Ambient temperature<br />5: α,α'-azobisisobutyronitrile, tributyltin hydride / toluene / 4 h / 70 &deg;C<br /> <br /> &nbsp;

&nbsp;Yield given. Multistep reaction;&nbsp;<br /> &nbsp;