bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine 16 h;

1.1: ethanol; water; calcium chloride; iron / 12.5 h / 75 °C 2.1: bromine / acetic acid / 16.5 h / 20 °C 2.2: 0 °C / pH 7 3.1: bromine; sodium nitrite; hydrogen bromide / water / 1.33 h / 0 °C 3.2: 1 h / 20 °C / pH 13 4.1: methanol / 3 h / 75 °C 5.1: triethylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 9 h / 20 - 40 °C / Inert atmosphere View Scheme

1.1: bromine / acetic acid / 16.5 h / 20 °C 1.2: 0 °C / pH 7 2.1: bromine; sodium nitrite; hydrogen bromide / water / 1.33 h / 0 °C 2.2: 1 h / 20 °C / pH 13 3.1: methanol / 3 h / 75 °C 4.1: triethylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 9 h / 20 - 40 °C / Inert atmosphere View Scheme

1.1: bromine; sodium nitrite; hydrogen bromide / water / 1.33 h / 0 °C 1.2: 1 h / 20 °C / pH 13 2.1: methanol / 3 h / 75 °C 3.1: triethylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 9 h / 20 - 40 °C / Inert atmosphere View Scheme

1: methanol / 3 h / 75 °C 2: triethylamine / triphenylphosphine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 9 h / 20 - 40 °C / Inert atmosphere View Scheme