2-氨基-4-溴苯甲酸乙酯合成路线 （共 6 条）
反应条件
1: With sodium hydroxide; ethanol; water T=25°C; 12 h; 2: With hydrogenchloride in ethanol; water pH=1 - 3;
参考文献
WO2005/123696 A1, ;
Page/Page column 66 ;
WO 2005/123696 A1
反应条件
caesium carbonate in N,N-dimethyl-formamide
T=20°C; 12 h; Inert atmosphere;
参考文献
DANA-FARBER CANCER INSTITUTE, INC.; WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH; BRADNER, James, E.; MCKEOWN, Michael, R.; RAHL, Peter, B.; YOUNG, Richard, A.; MARINEAU, Jason, J.
Patent: WO2014/71247 A1, 2014 ;
Location in patent: Paragraph 00332 ;
参考文献
Pfizer Inc.
Patent: US4762838 A1, 1988 ;
参考文献
Pfizer Inc.
Patent: US4762838 A1, 1988 ;
参考文献
Pfizer Inc.
Patent: US4762838 A1, 1988 ;
反应条件
1: sulfuric acid / toluene / 20 h / Reflux
2: acetic acid; zinc / methanol / 0 - 20 °C
View Scheme
参考文献
Smits, Rogier A.; Lim, Herman D.; Van Der Meer, Tiffany; Kuhne, Sebastiaan; Bessembinder, Karin; Zuiderveld, Obbe P.; Wijtmans, Maikel; De Esch, Iwan J.P.; Leurs, Rob
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 461 - 467
