2-氨基-5-三氟甲基苯甲酸甲酯合成路线 （共 9 条）
反应条件
triethylamine; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate in dimethyl sulfoxide T=80°C; P=5171.62 Torr; 14 - 16 h;
参考文献
WO2005/37796 A1, ;
Page/Page column 138 ;
反应条件
triethylamine; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=50°C; 120 h;
参考文献
EP1736465 A1, ;
Page/Page column 34 ;
反应条件
1: 2,2-dimethyl-N-(4-trifluoromethylphenyl)propanamide With n-butyllithium in tetrahydrofuran T=0°C; 3 h; 2: carbon dioxide in tetrahydrofuran T=20°C; Cooling with dry ice; 3: methanol With hydrogenchloride T=0 - 55°C;
参考文献
US2005/54627 A1, ;
Page/Page column 38 ;
US 20050054627 A1
反应条件
1: 2,2-dimethyl-N-(4-trifluoromethylphenyl)propanamide With n-butyllithium in tetrahydrofuran T=0°C; 3 h; 2: carbon dioxide in tetrahydrofuran T=0 - 20°C; 3: methanol With hydrogenchloride; sodium hydrogencarbonate more than 3 stages;
参考文献
US2005/54626 A1, ;
Page/Page column 34 ;
US 20050054626 A1
反应条件
trifluoroacetic acid in dichloromethane
反应条件
[iridium(III)(2-phenylpyridine)3] in N,N-dimethyl-formamide T=20°C; Inert atmosphereIrradiationSchlenk technique; Overall yield = 52 percent; regioselective reaction;
参考文献
Organic Letters, , vol. 16, # 6 p. 1768 - 1771
反应条件
thionyl chloride Reflux;
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 21 p. 8332 - 8338
反应条件
triethylamine in dichloromethane T=20°C; 72 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/37796 A1, 2005 ;
Location in patent: Page/Page column 138-139 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran
2 h; Cooling;
2: With sodium hydroxide; water in tetrahydrofuran
参考文献
Ajinomoto Co., Inc.
Patent: EP1736465 A1, 2006 ;
Location in patent: Page/Page column 34 ;
