((2R,3r)-3-(苯甲酰基氧基)-4,4-二氟-5-羟基四氢呋喃-2-基)甲基苯甲酸合成路线 （共 6 条）
反应条件
lithium tri-t-butoxyaluminum hydride in tetrahydrofuran; diethyl ether T=10 - 30°C; 1 h;
参考文献
Synthesis, , # 6 p. 565 - 570
反应条件
triethylamine in dichloromethane T=23°C; 2 h;
参考文献
Quintiliani, Maurizio; Persoons, Leentje; Solaroli, Nicola; Karlsson, Anna; Andrei, Graciela; Snoeck, Robert; Balzarini, Jan; McGuigan, Christopher
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 14 p. 4338 - 4345
反应条件
triethylamine in dichloromethane T=23°C; 2 h;
参考文献
Quintiliani, Maurizio; Persoons, Leentje; Solaroli, Nicola; Karlsson, Anna; Andrei, Graciela; Snoeck, Robert; Balzarini, Jan; McGuigan, Christopher
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 14 p. 4338 - 4345
反应条件
1: 100 percent / triethylamine / CH2Cl2 / 2 h / 23 °C 2: 1) Me3SiOTf / 1) 1,1,2-trichloroethane, r.t., 30 min, 2) 113 deg C, 18 h View Scheme
参考文献
Chou; Heath; Patterson; Poteet; Lakin; Hunt
Synthesis, 1992 , # 6 p. 565 - 570
反应条件
1: 1-bromo-2-deoxy-2,2-difluoro-D-ribofuranosyl-3,5-dibenzoate With triethylamine in tetrahydrofuran T=0 - 5°C; 2: (Ac)C(TMS)2 With trimethylsilyl trifluoromethanesulfonate in dichloromethane T=0 - 5°C; 3: in methanol T=40°C;
参考文献
KANNAN, Vishwanath; KASH, Vishwanathan
Patent: WO2010/29574 A2, 2010 ;
Location in patent: Page/Page column 8-9 ;
反应条件
1: 100 percent / triethylamine / CH2Cl2 / 2 h / 23 °C 2: 1) Me3SiOTf / 1) 1,1,2-trichloroethane, r.t., 30 min, 2) 113 deg C, 18 h View Scheme
参考文献
Chou; Heath; Patterson; Poteet; Lakin; Hunt
Synthesis, 1992 , # 6 p. 565 - 570
