6-(4-氯-3-硝基苯基)-4,5-二氢-5-甲基-3(2H)-吡嗪酮合成路线 （共 7 条）
反应条件
hydrazine hydrate in acetic acid T=100°C; 2.5 h;
参考文献
Jonas, R; Klockow, M; Lues, I; Pruecher, H; Schliep, H J; Wurziger, H
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 2 p. 129 - 140
反应条件
1: 54.6 percent / conc. HCl, water / Heating 2: 98 percent / nitric acid / 0.5 h / -15 - -10 °C 3: 98 percent / hydrazine hydrate / acetic acid / 2.5 h / 100 °C View Scheme
参考文献
EUROVET ANIMAL HEALTH B.V.
Patent: US2011/152283 A1, 2011 ;
反应条件
1: 98 percent / nitric acid / 0.5 h / -15 - -10 °C 2: 98 percent / hydrazine hydrate / acetic acid / 2.5 h / 100 °C View Scheme
参考文献
EUROVET ANIMAL HEALTH B.V.
Patent: US2011/152283 A1, 2011 ;
反应条件
1: sodium cyanide / dimethylformamide / 2 h / 40 °C 2: 54.6 percent / conc. HCl, water / Heating 3: 98 percent / nitric acid / 0.5 h / -15 - -10 °C 4: 98 percent / hydrazine hydrate / acetic acid / 2.5 h / 100 °C View Scheme
参考文献
EUROVET ANIMAL HEALTH B.V.
Patent: US2011/152283 A1, 2011 ;
反应条件
1.1: butan-1-ol; water 2.1: hydrogenchloride; hydrogen / palladium on carbon / water; methanol 3.1: sodium dithionite / N,N-dimethyl-formamide / 90 °C 3.2: 95 - 105 °C View Scheme
参考文献
EUROVET ANIMAL HEALTH B.V.
Patent: US2011/152283 A1, 2011 ;
反应条件
1: 86 percent / butan-1-ol / 20 h / Heating 2: 88.6 percent / H2, 1N aq. HCL / 5percent Pd/C / methanol / 2 h View Scheme
参考文献
EUROVET ANIMAL HEALTH B.V.
Patent: US2011/152283 A1, 2011 ;
反应条件
in butan-1-ol
20 h; Heating;
参考文献
Jonas, R; Klockow, M; Lues, I; Pruecher, H; Schliep, H J; Wurziger, H
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 2 p. 129 - 140
